Study of Knowledge Translation of Clinical Practice Guidelines for Ventilator Associated Pneumonia (ABATEVAP)

This study has been completed.
Sponsor:
Collaborators:
Kingston General Hospital
Canadian Institutes of Health Research (CIHR)
AstraZeneca
Bayer
Information provided by:
Canadian Critical Care Trials Group
ClinicalTrials.gov Identifier:
NCT00434460
First received: February 12, 2007
Last updated: August 31, 2010
Last verified: August 2010
  Purpose

The purpose of this prospective, multicentre, time-series study is to develop, implement, refine, and evaluate a sustainable behaviour change strategy in the intensive care unit (ICU).


Condition Intervention
Ventilator Associated Pneumonia
Behavioral: Education

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Active Observational Study of the Adoption and Transfer of Clinical Practice Guidelines Through Education, for Ventilator Associated Pneumonia (ABATE VAP Study)

Resource links provided by NLM:


Further study details as provided by Canadian Critical Care Trials Group:

Enrollment: 1320
Study Start Date: April 2007
Study Completion Date: July 2010
Groups/Cohorts Assigned Interventions
1
Patients receiving invasive mechanical ventilation > 48 hours.
Behavioral: Education
Implementation of clinical practice guideline for ventilator associated pneumonia through education.

Detailed Description:

Background:

In order to improve the care of our patients, it is necessary for research evidence to be translated into clinical practice. There are gaps in our understanding of knowledge translation (KT) and this is evident in the Intensive Care Unit (ICU), specifically as it applies to the prevention, diagnosis and treatment of ventilator-associated pneumonia (VAP). VAP is associated with a high burden of illness in the critically ill and there is an extensive amount of research evidence on this disease. It has been demonstrated that best practice as defined by research evidence is not uniformly applied to VAP. In addition, recent advances in VAP knowledge need be disseminated and implemented in order to improve patient safety and outcomes from VAP. A systematic process of knowledge transfer is crucial to translate this research into evidence-based bedside practice and the development and implementation of evidence based Clinical Practice Guidelines (CPGs) may facilitate VAP knowledge uptake. In addition, there is a need to study knowledge translation (KT) in the ICU since there is little information about optimal KT and CPG implementation strategies in this environment and efforts that are effective in other clinical areas may not result in meaningful change in the ICU.

Research Question:

What is the effect of VAP CPGs implemented by a multidisciplinary behaviour change strategy (consisting of multifaceted educational strategies led by local opinion leaders and augmented with reminders) on VAP guideline concordance and on clinical VAP outcomes in the ICU?

Research Plan:

Data will only be collected on consecutive patients mechanically ventilated for at least 48 hours. The following health care professionals will be studied to assess the behaviour change strategy for the VAP CPGs: physicians (intensivists, ICU fellows, ICU rotating residents), nurses, respiratory therapists, dieticians, physiotherapists and ICU administrators.

The study will be conducted in 3 phases:

  1. Development of a behaviour change strategy consisting of three components:

    • Local opinion leader team
    • Educational strategy
    • Reminder system
  2. Prospective implementation of the behaviour change strategy over a 24 month period
  3. Prospective evaluation of the behaviour change strategy over a 24 month period

    • Concordance with VAP guidelines over time
    • Factors associated with VAP guideline concordance
    • Clinical VAP outcomes pre- and post-guideline implementation
  Eligibility

Ages Eligible for Study:   17 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients invasively mechanically ventilated > 48 hours in the critical care setting.

Criteria

Inclusion Criteria:

  • Age >= 17 years old
  • Mechanically ventilated > 48 hours < 96 hours

Exclusion Criteria:

  • Previous enrollment in the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00434460

Locations
United States, Pennsylvania
Geisinger Health Centre, Temple University
Danville, Pennsylvania, United States, 17821-4400
Canada, British Columbia
Royal Columbian Hospital, University of British Columbia
New Westminister, British Columbia, Canada, V3L 3W4
St. Paul Hospital, University of British Columbia
Vancouver, British Columbia, Canada, V6Z 1Y6
Vancouver Island Health Research Centre
Victoria, British Columbia, Canada, V8R 1J8
Canada, Ontario
St. Joseph's Healthcare, McMaster University
Hamilton, Ontario, Canada, L8N 4A6
Kingston General Hospital, Queen's University
Kingston, Ontario, Canada, K7L 2V7
The Ottawa Hospital, University of Ottawa
Ottawa, Ontario, Canada, K1H 8L7
Thunder Bay Regional Health Sciences Centre
Thunder Bay, Ontario, Canada, P7B 6V4
William Osler Health Centre
Toronto, Ontario, Canada
Sunnybrook Health Sciences Centre, University of Toronto
Toronto, Ontario, Canada, M4N 3M5
Hotel Dieu Grace Hospital
Windsor, Ontario, Canada, N4A 1E1
Sponsors and Collaborators
Canadian Critical Care Trials Group
Kingston General Hospital
Canadian Institutes of Health Research (CIHR)
AstraZeneca
Bayer
Investigators
Study Chair: John Muscedere, MD Kingston General Hospital, Queen's University
Study Chair: Tasmin Sinuff, MD, PhD Sunnybrook Health Sciences Centre, University of Toronto
Principal Investigator: Daren Heyland, MD Kingston General Hospital, Queen's University
Principal Investigator: Deborah Cook, MD St. Joseph's Healthcare, McMaster University
Principal Investigator: Peter Dodek, MD St. Paul's University, University of British Columbia
Principal Investigator: Redouane Bouali, MD The Ottawa Hospital, University of Ottawa
Principal Investigator: Sean Keenan, MD Royal Columbian Hospital, University of British Columbia
Principal Investigator: Kevin Eva, PhD McMaster University
Principal Investigator: Brenda Morgan, RN London Health Sciences Centre, University of Western Ontario
Principal Investigator: Lori Hand, RRT Hamilton Health Sciences Centre, McMaster University
  More Information

Additional Information:
No publications provided by Canadian Critical Care Trials Group

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Dr. John Muscedere, Kingston General Hospital, Queen's University
ClinicalTrials.gov Identifier: NCT00434460     History of Changes
Other Study ID Numbers: ABATE VAP
Study First Received: February 12, 2007
Last Updated: August 31, 2010
Health Authority: Canada: Canadian Institutes of Health Research

Keywords provided by Canadian Critical Care Trials Group:
Ventilator Associated Pneumonia
Knowledge Translation
Clinical Practice Guidelines
Education
Behaviour Change

Additional relevant MeSH terms:
Pneumonia
Pneumonia, Ventilator-Associated
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Cross Infection
Infection
Ventilator-Induced Lung Injury
Lung Injury

ClinicalTrials.gov processed this record on October 19, 2014