Image Guided Radiation Therapy For Prostate Cancer
Recruitment status was Recruiting
During the 7 to 8 weeks of conformal radiotherapy for prostate carcinoma, the prostate has an intra-pelvic motion which is not detectable by the conventional portal imaging. This prostate motion may lead to a mistargeting, which possibly decreases the local control. On the other hand, the new 3D on board imaging (3D OBI) allows to localize the target but is expensive. The cost/effectiveness ratio is not well established, as well as the frequency of using such imaging during the course of radiation.
Procedure: Control position by 3DOBI before the fraction
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
|Official Title:||Economic Evaluation of Image Guided Radiation Therapy For Prostate Cancer|
- Prostate position under the LINAC is checked by 3D OBI (mainly cone-beam imaging, CBI) performed before the fraction.
- To validate the optimal strategy of IGRT for prostate adenocarcinoma based on 2 and 5 year-disease free survival rates (events= biochemical failure or death).
- Rectal and bladder, acute and late toxicities (CTCAE, SOMA-LENT)
- Cost comparison and cost/effectiveness analysis
- 2 and 5 years clinical relapse free survival rates
- Lack of dose in the prostate in case of decreasing the CBI frequency (using the 1rst arm for testing)
|Study Start Date:||June 2007|
|Estimated Study Completion Date:||September 2007|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00433706
|Contact: Renaud DE CREVOISIER, MD||00 33 1 42 11 45 firstname.lastname@example.org|
|Institut Gustave Roussy||Recruiting|
|Villejuif, France, 94805|
|Contact: Renaud DE CREVOISIER, MD 00 33 142 11 45 66 email@example.com|
|Principal Investigator:||Renaud DE CREVOISIER, MD||Gustave Roussy, Cancer Campus, Grand Paris|