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| Sponsors and Collaborators: |
University of Mississippi Medical Center Ohio State University |
| Information provided by: | University of Mississippi Medical Center |
| ClinicalTrials.gov Identifier: | NCT00433355 |
Purpose
The purpose of this study is to understand what causes a continuing fatigue for a long time with a number of symptoms occurring at the same time (Chronic Fatigue Syndrome-CFS). Epstein Barr Virus is among the group of viruses that have been associated with a continuing fatigue for a long time with a number of symptoms occurring at the same time, but the cause is still unknown.
| Condition |
|
Chronic Fatigue Syndrome |
| MedlinePlus related topics: | Chronic Fatigue Syndrome |
| Study Type: | Observational |
| Study Design: | Case Control, Prospective |
| Official Title: | Studies on Epstein-Barr Virus as a Possible Etiological Agent for Chronic Fatigue Syndrome |
| Estimated Enrollment: | 150 |
| Study Start Date: | December 2006 |
| Estimated Study Completion Date: | October 2008 |
Epstein-Barr virus (EBV) is the etiological agent for heterophile positive infectious mononucleosis (IM). It is also an oncogenic herpes virus associated with African Burkitt's lymphoma (BL),nasopharyngeal carcinoma (NPC) and AIDS-associated B-cell lymphomas. EBV is also among a group of viruses that have been associated with chronic fatigue syndrome (CFS), although the etiology of CFS still remains unknown.Findings may lead to hypothesize that EBV enzymes, such as the dUTPase, have the capacity to induce immune dysregulation of the T-cell and NK cell responses and that this immune dysregulation produces immunopathology that results in the symptoms that we call CFS.
Eligibility
| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
18 y/o and above with history of CFS matched those without as to age and gender.
Inclusion Criteria:
Exclusion Criteria:
Note: We recruit participants in the Mississippi area who could come in our site to provide blood draw.
Contacts and Locations| Contact: Sheila Belk, BS | 601-815-5374 | sbelk@medicine.umsmed.edu |
| Contact: Denise Montgomery, BS | 601-815-5648 | dmontgomery@medicine.umsmed.edu |
| United States, Mississippi | |||||
| University of Mississippi Medical Center | Recruiting | ||||
| Jackson, Mississippi, United States, 39216-4505 | |||||
| Principal Investigator: Gailen D. Marshall, M.D., PhD | |||||
| University of Mississippi Medical Center |
| Ohio State University |
| Principal Investigator: | Gailen D Marshall, M.D., PhD | University of Mississippi Medical Center |
More Information
| Responsible Party: | The University of Mississippi Medical Center ( Gailen D. Marshall, MD, PhD ) |
| Study ID Numbers: | 2006-0265 |
| First Received: | February 7, 2007 |
| Last Updated: | May 2, 2008 |
| ClinicalTrials.gov Identifier: | NCT00433355 |
| Health Authority: | United States: Institutional Review Board |
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