Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)
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Purpose
The machines and oxygen used to help very premature babies breathe can have side-effects, such as bronchopulmonary dysplasia (BPD). Infants with BPD get more complications (a higher death rate, a longer time in intensive care and on assisted ventilation, more hospital readmissions in the first year of life, and more learning problems) than infants who do not develop BPD. Doctors try to remove the tube in the wind-pipe that links the baby to the breathing machine as soon as possible. However, small babies get tired, and still require help to breathe. One of the standard and common techniques to help them breathe without a tube in the wind-pipe is to use simple pressure support, nasal continuous positive airway pressure or nCPAP. This supports breathing a little, but it is often not enough to prevent the need to go back on the breathing machine.
Nasal intermittent positive pressure ventilation (NIPPV) is similar to nCPAP, but also gives some breaths, or extra support, to babies through a small tube in the nose. NIPPV is safe and effective, and already in use as an alternate "standard" therapy.
The main research question: After being weaned from the breathing machine, is NIPPV better than nCPAP in preventing BPD in premature babies weighing 999 grams or less at birth?
| Condition | Intervention | Phase |
|---|---|---|
|
Respiratory Insufficiency of Prematurity |
Device: nCPAP Device: NIPPV |
Phase 3 |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Prevention |
| Official Title: | Efficacy and Safety of NIPPV to Increase Survival Without Bronchopulmonary Dysplasia in Extremely Low Birth Weight Infants |
- Composite of survival to 36 weeks gestational age, free of moderate-severe bronchopulmonary dysplasia [ Time Frame: 36 weeks gestational age ] [ Designated as safety issue: Yes ]
- All cause mortality at 36 weeks gestational age [ Time Frame: 36 weeks gestational age ] [ Designated as safety issue: Yes ]
- All cause mortality before first discharge home [ Time Frame: first discharge home ] [ Designated as safety issue: Yes ]
- retinopathy of prematurity [ Time Frame: discharge home ] [ Designated as safety issue: Yes ]
- ultrasonographic evidence of brain injury [ Time Frame: 36 weeks gestional age ] [ Designated as safety issue: Yes ]
- necrotizing enterocolitis [ Time Frame: 36 weeks gestational age ] [ Designated as safety issue: Yes ]
- growth [ Time Frame: discharge home ] [ Designated as safety issue: Yes ]
- time to establish full feeds [ Time Frame: discharge home ] [ Designated as safety issue: Yes ]
- nosocomial infections [ Time Frame: discharge home ] [ Designated as safety issue: No ]
- need for re-intubation [ Time Frame: 36 weeks gestational age ] [ Designated as safety issue: Yes ]
- time on supplemental oxygen [ Time Frame: discharge home ] [ Designated as safety issue: No ]
- duration of positive pressure respiratory support [ Time Frame: discharge home ] [ Designated as safety issue: Yes ]
- comparison of synchronized and non-synchronized NIPPV [ Time Frame: discharge home ] [ Designated as safety issue: No ]
- bronchopulmonary dysplasia [ Time Frame: 36 weeks gestational age ] [ Designated as safety issue: Yes ]
- air leak syndromes [ Time Frame: 36 weeks gestational age ] [ Designated as safety issue: Yes ]
- nasal trauma [ Time Frame: discharge home ] [ Designated as safety issue: Yes ]
| Enrollment: | 1011 |
| Study Start Date: | April 2007 |
| Study Completion Date: | December 2011 |
| Primary Completion Date: | August 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Active Comparator: A
Non-invasive respiratory support via nasal intermittent positive pressure ventilation
|
Device: NIPPV
Deliver non-invasive respiratory support via ventilator with NIPPV device
Other Name: NIPPV
|
|
Active Comparator: B
Non-invasive respiratory support via nasal Continuous Positive Airway Pressure
|
Device: nCPAP
Deliver non-invasive respiratory support via ventilator with nCPAP device
Other Name: nCPAP
|
Detailed Description:
The immature lung of extremely low birth weight (ELBW, < 1000 g) infants is easily damaged by the placement of an endotracheal tube to deliver mechanical ventilation and oxygen. This and the total time of mechanical ventilation contributes to bronchopulmonary dysplasia (BPD). Infants with BPD have an increased risk of later death or neuro-impairment. With the increasing survival of ELBW infants in the NICU, there has been a proportionate increase in the number of infants surviving with BPD.
Following invasive ventilation via an endotracheal tube (ETT), extubation to nasal Continuous Positive Airway Pressure (nCPAP)ventilation is the standard approach. Currently, 40% of infants who are extubated and given nCPAP support fail, and require re-intubation. Previous work suggests that a less invasive respiratory support such as Nasal Intermittent Positive Pressure Ventilation (NIPPV), without an endotracheal tube is less injurious to the lung. NIPPV may thereby reduce the duration of invasive ventilator support, and aid successful early extubation. We hypothesize that the use of NIPPV leads to a higher rate of survival without BPD than standard therapy with nCPAP.
This randomized clinical trial is appropriately powered to compare NIPPV with nCPAP to detect effects on clinically relevant long-term outcomes, such as death and BPD at 36 weeks. This is a multi-national, randomized, open clinical trial of two different standard methods of providing non-invasive respiratory support to 1000 extremely preterm infants weighing less than 1000 grams at birth.
Eligibility| Ages Eligible for Study: | up to 28 Days |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Birth weight <1000 gm
- Gestational age <30 completed weeks
Intention to manage the infant with non-invasive respiratory support (i.e. no endotracheal tube), where either:
- the infant is within the first 7 days of life and has never been intubated or has received less than 24 hours of total cumulative intubated respiratory support;
- the infant is within the first 28 days of life, has been managed with intubated respiratory support for 24 hours or more and is a candidate for extubation followed by non-invasive respiratory support.
Exclusion Criteria:
- Considered non-viable by clinician (decision not to administer effective therapies)
- Life-threatening congenital abnormalities including congenital heart disease (excluding patent ductus arteriosis)
- Infants known to require surgical treatment
- Abnormalities of the upper and lower airways
- Neuromuscular disorders
- Infants who are >28 days old and continue to require mechanical ventilation with an endotracheal tube
Contacts and Locations
Show 37 Study Locations| Study Chair: | Haresh Kirpalani, MD, MSc | Hamilton Health Sciences Corporation |
| Study Director: | Brigitte Lemyre, MD | Children's Hospital of Eastern Ontario |
| Study Director: | Aaron Chiu, MD | St. Boniface General Hospital Research Centre |
| Study Director: | David Millar, MD | Royal Maternity Hospital, Belfast |
| Study Director: | Robin S Roberts, MTech | Hamilton Health Sciences/McMaster University |
| Study Director: | Bradley Yoder, MD | University of Utah |
| Study Director: | Peter H Dijk, MD, PhD | University Medical Centrum Groningen |
More Information
No publications provided
| Responsible Party: | Haresh Kirpalani, Nominated PI, McMaster University |
| ClinicalTrials.gov Identifier: | NCT00433212 History of Changes |
| Other Study ID Numbers: | NTG-2007-NIPPV, CIHR MCT-80246, ISRCTN15233270 |
| Study First Received: | February 7, 2007 |
| Last Updated: | March 7, 2012 |
| Health Authority: | Canada: Ethics Review Committee |
Keywords provided by McMaster University:
|
prematurity respiratory insufficiency non-invasive ventilation bronchopulmonary dysplasia hyaline membrane disease |
Additional relevant MeSH terms:
|
Bronchopulmonary Dysplasia Respiratory Insufficiency Ventilator-Induced Lung Injury Lung Injury Lung Diseases |
Respiratory Tract Diseases Infant, Premature, Diseases Infant, Newborn, Diseases Respiration Disorders |
ClinicalTrials.gov processed this record on May 22, 2013