Acute Single Meal Effects of Trout on Cardiovascular Risk Markers and Plasma Proteome
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Purpose
The acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated.
The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.
| Condition | Intervention |
|---|---|
|
Cardiovascular Diseases Metabolic Syndrome |
Behavioral: Intake of rainbow trout from different feeding conditions versus a control poultry meal |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Bio-availability Study Intervention Model: Crossover Assignment Masking: Single Blind Primary Purpose: Prevention |
- plasma protein expression
- Blood Pressure
- Pulse Wave Analysis
- Pulse wave Velocity
- Plasma Triglycerides
| Estimated Enrollment: | 6 |
| Study Start Date: | January 2007 |
| Estimated Study Completion Date: | January 2009 |
| Primary Completion Date: | March 2007 (Final data collection date for primary outcome measure) |
In a controlled, single blinded human single meal study the acute effects of farmed rainbow trout, fed by various feeds versus a control meal with poultry meat on cardiovascular risk markers and plasma protein expression are investigated. 6 healthy men, age 40-70, will be randomized to trout fed on only vegetable, only marine and a mix of different compositions of vegetable and marine feeds. Outcome variables are blood pressure, pulse wave analyse, pulse wave velocity, plasma protein profile, and plasma triglycerides.
The hypotheses of the study are that if the feed are changed from a marine origin to primarily a vegetable origin the content of long chain n-3 poly unsaturated fatty acids (n-3 PUFA) will decrease in the meat and thus possibly result in a decreased effect on health. Furthermore, the feed of the trouts are also expected to give rise to differences in the human plasma protein profile and fatty acid composition after consumption, which could be associated with physiological effects.
Eligibility| Ages Eligible for Study: | 40 Years to 70 Years |
| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Non regular smokers
- Body Mass Index (18.5-30 kg/m2)
- Able to eat fish
Exclusion Criteria:
- Exercise >10 h/week
- Chronical diseases (eg. cardiovascular and diabetes)
- Regular medication
- Fish oil supplementation
- Blood donation 2 month prior or during participation
- Above maximum recommended alcohol intake
- Blood pressure >160/100 mm Hg
Contacts and Locations| Denmark | |
| Institute of Human Nutrition, University of Copenhagen | |
| Frederiksberg C, Denmark, 1958 | |
| Principal Investigator: | Lotte Lauritzen, Ph.D | University of Copenhagen |
More Information
No publications provided
| Responsible Party: | Associate profesor Lotte lauritzen, Dept. of Human Nutrtion |
| ClinicalTrials.gov Identifier: | NCT00432952 History of Changes |
| Other Study ID Numbers: | M186 |
| Study First Received: | February 7, 2007 |
| Last Updated: | August 12, 2008 |
| Health Authority: | Denmark: The Danish National Committee on Biomedical Research Ethics |
Keywords provided by University of Copenhagen:
|
Cardiovascular Heart Disease |
Additional relevant MeSH terms:
|
Cardiovascular Diseases Metabolic Syndrome X Insulin Resistance |
Hyperinsulinism Glucose Metabolism Disorders Metabolic Diseases |
ClinicalTrials.gov processed this record on May 23, 2013