Hormonal Levels in Men With Major Depressive Disorder

This study has been withdrawn prior to enrollment.
Information provided by:
Sheba Medical Center
ClinicalTrials.gov Identifier:
First received: January 31, 2007
Last updated: August 28, 2011
Last verified: August 2011

Subjects will be 1000 men meeting the following inclusion criteria: 1) male, age 18-65 years; 2) meeting DSM-IV criteria for major depressive disorder within the past one year, with a HAM-D score >12.

Subjects will be excluded if they exhibit 1) a substance abuse or dependence disorder within the past year; 2) current psychotic symptoms; or 3) a history of bipolar disorder.


After informed consent, eligible patients will have blood drawn for serum hormone levels; cortisol, DHEA-S and testosterone or they will provide a salivary sample for measurement of hormone levels.

We will also test hormone level form 1000 healthy males (from blood or saliva) at the same age for comparison.

Condition Intervention
Procedure: Saliva sample

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Hormonal Levels in Men With Major Depressive Disorder

Resource links provided by NLM:

Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 2000

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Men diagnosed with Major depression disorder


Inclusion Criteria:

  • Male
  • Major Depression Disorder
  • 18-65
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00429689

Sponsors and Collaborators
Sheba Medical Center
Study Director: Stuart Seidman,, MD West End Medical Associates
Principal Investigator: Revital Amiaz, MD Sheba Medical Center
  More Information

No publications provided

Responsible Party: Amiaz Revital, MD, Sheba Medical Center
ClinicalTrials.gov Identifier: NCT00429689     History of Changes
Other Study ID Numbers: SHEBA-06-4480-RA-CTIL
Study First Received: January 31, 2007
Last Updated: August 28, 2011
Health Authority: Israel: The Israel National Institute for Health Policy Research and Health Services Research

Keywords provided by Sheba Medical Center:
Male, MDD, Testosterone, DHEA-S,Cortisol
Major Depression

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on April 15, 2014