Continuous Exhaled Breath Condensate pH in Mechanically Ventilated Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2008 by University of Virginia.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of Virginia
ClinicalTrials.gov Identifier:
NCT00429637
First received: January 30, 2007
Last updated: August 6, 2008
Last verified: August 2008
  Purpose

Given the possible prognostic relationship between exhaled breath condensate pH and clinical symptoms, it is quite plausible that exhaled breath condensate pH can prove useful in the intensive care unit. For example, if exhaled breath condensate pH falls prior to the onset of clinical symptoms, it is likely that it can be useful as an early marker, heralding the onset of various inflammatory lung diseases. Specifically, exhaled breath condensate pH could be used as a safe, non-invasive screening tool for Ventilator Associated Pneumonia. Similarly, just as changes in exhaled breath condensate pH might predict the onset of disease, exhaled breath condensate pH changes might also mark the progression or resolution of disease (e.g. alerting clinicians to possible readiness for extubation). Although such notions are hypothetical, they are beginning to be supported by anecdotal evidence.


Condition Phase
Respiratory Distress Syndrome, Adult
Respiratory Syncytial Virus Infections
Pneumonia
Acute Lung Injury
Phase 2

Study Type: Observational
Official Title: Phase 2 Continuous Exhaled Breath Condensate pH in Mechanically Ventilated Patients

Resource links provided by NLM:


Further study details as provided by University of Virginia:

Estimated Enrollment: 120
Study Start Date: December 2004
Estimated Study Completion Date: January 2009
  Show Detailed Description

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Any intubated patients, aged birth to adulthood, who are on a ventilator in any University of Virginia (UVA) intensive care unit.

Exclusion Criteria:

  • Control subjects may not be taking oral or inhaled steroids or have asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, bacterial or viral pneumonitis, or adult respiratory distress syndrome (ARDS).
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00429637

Contacts
Contact: Brian K Walsh, BS, RRT 434-243-9324 bkw2j@virginia.edu
Contact: John F Hunt, MD 434-243-9324 jhunt@virginia.edu

Locations
United States, Virginia
University of Virginia Recruiting
Charlottesville, Virginia, United States, 22908
Contact: Brian K Walsh, BS, RRT    434-243-9324    bkw2j@virginia.edu   
Contact: John F Hunt, MD    434-243-9324    jhunt@virginia.edu   
Sponsors and Collaborators
University of Virginia
Investigators
Principal Investigator: John F Hunt, MD University of Virginia
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00429637     History of Changes
Other Study ID Numbers: 11618
Study First Received: January 30, 2007
Last Updated: August 6, 2008
Health Authority: United States: Institutional Review Board

Keywords provided by University of Virginia:
EBC pH
Airway acidification
Condensimetry
ARDS
RSV
ALI
Airway reconstruction

Additional relevant MeSH terms:
Respiratory Syncytial Virus Infections
Acute Lung Injury
Lung Injury
Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Newborn
Virus Diseases
Infant, Newborn, Diseases
Infant, Premature, Diseases
Lung Diseases
Mononegavirales Infections
Paramyxoviridae Infections
Pneumovirus Infections
Respiration Disorders
Respiratory Tract Diseases
RNA Virus Infections
Thoracic Injuries
Wounds and Injuries

ClinicalTrials.gov processed this record on October 30, 2014