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Neuromuscular and Cognitive Fatigue During a 24 Hour Treadmill Running Exercise

This study has been completed.
Sponsor:
Information provided by:
Centre Hospitalier Universitaire de Saint Etienne
ClinicalTrials.gov Identifier:
NCT00428779
First received: January 29, 2007
Last updated: June 10, 2009
Last verified: June 2009
History of Changes
  Purpose

The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.


Condition Intervention
Healthy
 Procedure: running during 24 hours without sleep
Other: no sleeping

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: Neuromuscular and Cognitive Fatigue During a 24h Treadmill Running Exercise.

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Centre Hospitalier Universitaire de Saint Etienne:

Primary Outcome Measures:
  • -Voluntary and electrically evoked forces on the contracted muscles [ Time Frame: 24 hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Electrically evoked forces on the relaxed muscles and associated EMG activity [ Time Frame: 24 hours ] [ Designated as safety issue: No ]
  • Blood samples before the exercise [ Time Frame: every 4 hours ] [ Designated as safety issue: No ]
  • Muscle biopsy (vastus lateralis) [ Time Frame: before and after the exercise ] [ Designated as safety issue: No ]

Enrollment: 30
Study Start Date: September 2007
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
patients running during 24 hours without sleep
 Procedure: running during 24 hours without sleep
patients running during 24 hours without sleep
Placebo Comparator: 2
patients without sleep during 24 hours
 Other: no sleeping
patients without sleep during 24 hours

Detailed Description:

For that purpose, 14 subjects running 24 hours on a treadmill will be compared with a control group being awake during the same period. Subjects who running will have electrically evoked forces on the muscles associated EMG activity, blood samples and muscle biopsy.

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer.
  • The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years.

Exclusion Criteria:

  • The subjects will not be selected if:

    • they were injured in the 3 months before the experiment
    • they had a tendon or joint pathology that could impair strength measurements.
    • they participate to an other experiment at the same time
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00428779

Locations
France
Pr André GEYSSANT
Saint-etienne, France, 42055
Sponsors and Collaborators
Centre Hospitalier Universitaire de Saint Etienne
Investigators
Study Chair: DENIS Christian, Professor Service de médecine du sport, CHU SAINT-ETIENNE
  More Information

Publications:

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Clément CAILLAUX, CHU de Saint-Etienne
ClinicalTrials.gov Identifier: NCT00428779     History of Changes
Other Study ID Numbers: 0601095, DGS 2006-0111, 2006-A00312-49
Study First Received: January 29, 2007
Last Updated: June 10, 2009
Health Authority: France: Ministry of Health

Keywords provided by Centre Hospitalier Universitaire de Saint Etienne:
Running during 24 hours
Voluntary evoked force on the muscles
Electrically evoked force on the muscles
 EMG activity
Muscle biopsy
subjects will be recruited among experienced ultra-runners

ClinicalTrials.gov processed this record on June 18, 2013