Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

This study has been completed.

First Received: January 19, 2007 Last Updated: February 4, 2009 History of Changes

Sponsor:	University of Aarhus
Information provided by:	University of Aarhus
ClinicalTrials.gov Identifier:	NCT00424957

Purpose

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Condition
Cirrhosis Hepatic Encephalopathy

Study Type:	Observational
Study Design:	Case Control, Cross-Sectional
Official Title:	Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Resource links provided by NLM:

MedlinePlus related topics: Cirrhosis Liver Diseases

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Biospecimen Retention: None Retained

Biospecimen Description:

Estimated Enrollment:	18
Study Start Date:	November 2006
Study Completion Date:	October 2008
Primary Completion Date:	April 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	45 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects age and sex matched

Criteria

Inclusion Criteria:

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
6 healthy subjects age and sex matched

Exclusion Criteria:

Neurological and/or psychiatric condition,
Non-treated diabetes,
Pregnancy/breast-feeding

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00424957

Locations

Denmark
PET Centre, Aarhus University Hospital
Aarhus, Denmark, 8000

Sponsors and Collaborators

University of Aarhus

Investigators

Study Chair:

Susanne Keiding, MD

PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital

More Information

Additional Information:

Liver research group at PET Centre, Aarhus University Hospital This link exits the ClinicalTrials.gov site

Publications:

Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. Review.

Responsible Party:	PET Center, Aarhus University Hospital ( Peter Iversen )
Study ID Numbers:	20060120
Study First Received:	January 19, 2007
Last Updated:	February 4, 2009
ClinicalTrials.gov Identifier:	NCT00424957 History of Changes
Health Authority:	Denmark: Ethics Committee; Denmark: The Danish National Committee on Biomedical Research Ethics; Denmark: Danish Dataprotection Agency

Keywords provided by University of Aarhus:

Ammonia
Astrocytes
Citric acid cycle
Alpha ketoglutarate dehydrogenase

Additional relevant MeSH terms:

Liver Diseases
Neurotoxicity Syndromes
Fibrosis
Brain Damage, Chronic
Disorders of Environmental Origin
Central Nervous System Viral Diseases
Brain Diseases
Signs and Symptoms
Pathologic Processes
Mental Disorders
Neurobehavioral Manifestations
Hepatic Insufficiency
Delirium
Liver Failure

Metabolic Diseases
Nervous System Diseases
Poisoning
Central Nervous System Diseases
Confusion
Encephalitis
Virus Diseases
Hepatic Encephalopathy
Digestive System Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Central Nervous System Infections
Neurologic Manifestations
Brain Diseases, Metabolic

ClinicalTrials.gov processed this record on February 08, 2010