Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System - Full Text View

Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

This study is currently recruiting participants.
Verified by University of Aarhus, July 2007

Sponsored by:	University of Aarhus
Information provided by:	University of Aarhus
ClinicalTrials.gov Identifier:	NCT00424957

Purpose

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.

Condition

Cirrhosis
Hepatic Encephalopathy

MedlinePlus related topics:

Cirrhosis Liver Diseases

ChemIDplus related topics:

Citric acid Sodium Citrate alpha-Ketoglutaric acid Ammonia

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Case Control, Retrospective/Prospective Study

Official Title:	Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Further study details as provided by University of Aarhus:

Estimated Enrollment:	18
Study Start Date:	November 2006
Estimated Study Completion Date:	November 2007

Eligibility

Ages Eligible for Study:	45 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
6 healthy subjects age and sex matched

Exclusion Criteria:

Neurological and/or psychiatric condition,
Non-treated diabetes,
Pregnancy/breast-feeding

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00424957

Contacts


Contact: Susanne Keiding, MD	+45 8949 3031	susanne@pet.auh.dk

Locations


Denmark
	PET Centre, Aarhus University Hospital	Recruiting
	Aarhus, Denmark, 8000
	Contact: Peter Iversen, MD +45 8949 4405 piv@pet.auh.dk
	Principal Investigator: Peter Iversen, MD

Sponsors and Collaborators

University of Aarhus

Investigators


Study Chair:	Susanne Keiding, MD	PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital

More Information

Liver research group at PET Centre, Aarhus University Hospital This link exits the ClinicalTrials.gov site

Publications:

Ott P, Clemmesen O, Larsen FS. Cerebral metabolic disturbances in the brain during acute liver failure: from hyperammonemia to energy failure and proteolysis. Neurochem Int. 2005 Jul;47(1-2):13-8. Review.

Study ID Numbers:	20060120
First Received:	January 19, 2007
Last Updated:	July 11, 2007
ClinicalTrials.gov Identifier:	NCT00424957
Health Authority:	Denmark: Ethics Committee; Denmark: The Danish National Committee on Biomedical Research Ethics; Denmark: Danish Dataprotection Agency

Keywords provided by University of Aarhus:

Ammonia

Astrocytes

Citric acid cycle

Alpha ketoglutarate dehydrogenase

Study placed in the following topic categories:

Liver Failure

Liver Diseases

Metabolic Diseases

Fibrosis

Citric Acid

Central Nervous System Diseases

Liver Cirrhosis

Brain Diseases

Hepatic Encephalopathy

Digestive System Diseases

Metabolic disorder

Hepatic Insufficiency

Brain Diseases, Metabolic

Additional relevant MeSH terms:

Pathologic Processes

Nervous System Diseases

ClinicalTrials.gov processed this record on August 29, 2008