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Prognostic Significance of the Baroreflex Sensitivity Changes After Acute Ischemic Stroke

This study is currently recruiting participants.
Verified by Far Eastern Memorial Hospital, July 2008

Sponsored by: Far Eastern Memorial Hospital
Information provided by: Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT00422474
  Purpose

After acute stroke, baroreflex sensitivity (BRS) is impaired. This impaired acute stage BRS has been reported to be predictive of worsen outcome years after stroke in general. However, it is not very clear if the impaired acute stroke BRS would actually persist months after the acute stage. It is also not clear that such change, if any, would correlate with the functional outcome or prognosis after stroke.

The trial is to investigate the longitudinal time course of BRS after ischemic stroke up to the 6th month post stroke and to see if there is any correlation of the changes in BRS with the functional outcome parameters using NIHSS and mRS scores throughout this period.


Condition
Cerebrovascular Accident
Baroreflexes
Autonomic Nervous System Diseases

MedlinePlus related topics:   Autonomic Nervous System Disorders    Neurologic Diseases   

U.S. FDA Resources

Study Type:   Observational
Study Design:   Prospective
Official Title:   Noninvasive Study of the Time Course of Baroreflex Sensitivity 6-Month After Acute Ischemic Stroke and the Relation of Its Changes With Post Stroke Prognosis

Further study details as provided by Far Eastern Memorial Hospital:

Estimated Enrollment:   100
Study Start Date:   January 2007

  Eligibility
Ages Eligible for Study:   50 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Criteria

Inclusion Criteria:

  • Baroreflex sensitivity can be done within 72 hours of onset of acute ischemic stroke
  • 50-80 years old
  • Must have either brain CT or brain MRI done

Exclusion Criteria:

  • NIHSS score > 10
  • Patient could not cooperate
  • Unstable vital sign
  • Atrial fibrillation
  • Transient ischemic attack patient
  • Diabetic patient
  • Impaired renal function (Cr > 2.26 mg/dl)
  • Unstable angina, acute myocardiac infarction, cardiomyopathy patients
  • Patient who has known autonomic dysfunction
  Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00422474

Contacts
Contact: Siupak Lee, M.D.     siupakmd@ms1.hinet.net    

Locations
Taiwan, Taipei County
Far Eastern Memorial Hospital     Recruiting
      Panchiao City, Taipei County, Taiwan, 220
      Contact: Siupak Lee, M.D.         siupakmd@ms1.hinet.net    
      Principal Investigator: Siupak Lee, M.D.            
      Sub-Investigator: Lung Chan, M.D.            
      Sub-Investigator: Dong-feng Yeih, M.D.            

Sponsors and Collaborators
Far Eastern Memorial Hospital

Investigators
Principal Investigator:     Siupak Lee, M.D.     Far Eastern Memorial Hospital    
  More Information

Responsible Party:   Far Eastern Memorial Hospital ( Dr. Siupak Lee )
Study ID Numbers:   FEMH-95-C-012
First Received:   January 14, 2007
Last Updated:   July 8, 2008
ClinicalTrials.gov Identifier:   NCT00422474
Health Authority:   Taiwan: Department of Health

Keywords provided by Far Eastern Memorial Hospital:
Ischemic stroke  
Baroreflex sensitivity  
Prognosis  
Cardiovascular autonomic regulation  

Study placed in the following topic categories:
Autonomic Nervous System Diseases
Cerebral Infarction
Stroke
Vascular Diseases
Central Nervous System Diseases
Brain Ischemia
Brain Infarction
Ischemia
Brain Diseases
Infarction
Cerebrovascular Disorders

Additional relevant MeSH terms:
Nervous System Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on September 04, 2008




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