Interruption of Dorsal Visual Stream Using TMS

This study has been completed.
Sponsor:
Information provided by:
Sheba Medical Center
ClinicalTrials.gov Identifier:
NCT00418652
First received: January 4, 2007
Last updated: August 3, 2011
Last verified: August 2011
  Purpose

Trans Cranial Magnetic Stimulation (TMS) over dorsal visual system will disturb the ability to identify objects with decreased level of fragmentation


Condition Intervention
Healthy
Device: No TMS intervention
Device: TMS over the PO3 EEG site
Device: TMS over the vertex

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Diagnostic
Official Title: Interruption of Dorsal Visual Stream Using TMS in Normal Controls

Further study details as provided by Sheba Medical Center:

Primary Outcome Measures:
  • Results of the study assignments performed by the participants during the study. [ Time Frame: The participants performed the tasks once during their study visit ] [ Designated as safety issue: No ]

    The subjects performed 2 tasks:

    The primary dependent measures consisted of the level of detail needed for correct object identification, response accuracy, and response time in milliseconds for correct responses.

    Illusory Contour Task: Subjects also performed a pulsed pedestal task, Participants were shown 55 drawings for 500 ms each. Some drawings contained partial contours which defined a geometric shape, while in others the contours did not define a shape. Participants were asked to indicate whether they recognized a geometric shape or not. Accuracy and response time were measured.



Enrollment: 12
Study Start Date: January 2006
Primary Completion Date: July 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: No TMS stimulation
The patients performed 2 tasks: a study and a control assignments with no TMS stimulation.
Device: No TMS intervention
In the "no TMS" condition, no simulation was given and no coil placed near participants' heads.
Experimental: TMS over the dorsal stream
The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the dorsal stream area (PO3 EEG site).
Device: TMS over the PO3 EEG site
10Hz TMS over the dorsal stream (PO3 EEG site)
Other Name: MAGSTIM biphasic stimulator
Sham Comparator: TMS over the vertex
The patients performed 2 tasks: a study and a control assignments under TMS stimulation over the vertex area.
Device: TMS over the vertex
10Hz TMS for over vertex.
Other Name: MAGSTIM biphasic stimulator

Detailed Description:

The participants performed two tasks under three different TMS conditions: no TMS, 10Hz TMS for over the dorsal stream (PO3 EEG site) or over the vertex.

First they performed a perceptual closure task which asked them to identify an object in a series of six progressively less degraded pictures.

Then, they also performed a control task previously shown not to be mediated by the LOC and not to be impaired in schizophrenia: The perception of illusory contours.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Normal controls

Exclusion Criteria:

  • neurological, ophthalmological or psychiatric problems
  • family history of schizophrenia
  • left handed
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00418652

Locations
Israel
Psychiatry Clinic - Sheba Medical Center
Tel-hashomer, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center
Investigators
Principal Investigator: Revital Amiaz, MD Sheba Medical Center
  More Information

No publications provided

Responsible Party: Amiaz Revital, MD - Senior Psychiatrist, Sheba Medical Center
ClinicalTrials.gov Identifier: NCT00418652     History of Changes
Other Study ID Numbers: SHEBA-06-4252-RA-CTIL
Study First Received: January 4, 2007
Last Updated: August 3, 2011
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:
Normal Controls

ClinicalTrials.gov processed this record on September 18, 2014