A Follow-up, Family Study on Attention-deficit Hyperactivity Disorder

This study has been completed.
Sponsor:
Collaborator:
National Health Research Institutes, Taiwan
Information provided by (Responsible Party):
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00417781
First received: December 31, 2006
Last updated: November 12, 2012
Last verified: April 2012
  Purpose

Background: Attention deficit hyperactivity disorder (ADHD), characterized by inattention, hyperactivity and impulsivity, is an early onset, common (5-10% worldwide; 7.5% in Taiwan), clinically heterogeneous, impairing disorder. Despite the abundance of research on ADHD, the vast majority of samples have been limited to Caucasians; there is limited information about the expressions, patterns, correlates, and outcomes for ADHD in the Taiwanese population.

Specific Aims:

  1. to investigate the neuropsychological functioning, and psychiatric, academic, and social outcomes of ADHD at adolescence;
  2. to examine the psychopathology and neuropsychological functioning among parents and siblings of ADHD probands;
  3. to determine the components of ADHD and neuropsychological functioning with the greatest familial recurrence risks; and
  4. to validate the classification of ADHD and comorbid subtypes of ADHD using psychosocial, familial, neuropsychological and longitudinal data.

Subjects and Methods: This 5-year proposal consists of two parts: (1) a 3 year-retrospective cohort study and family study design; and (2) a 2 year-prospective cohort study design. Several Chinese version of rating scales will be prepared in the first 6 months. The sample will consist of probands with (n=180) and without (n=90) ADHD, ages 11-16, recruited from the Children's Mental Health Center, NTUH and an epidemiological study. The ADHD diagnosis has been made 3-6 years ago prior to recruitment. Probands and their parents will be assessed using the following measures (n=810) in the first 3 years. Only probands will be reassessed in the last 2 years. The measures will include a psychiatric interview using K-SADS-E and self-reports covering the individual and familial/environmental domains; and neuropsychological tests (WISC-III, CPT, WCST, CANTAB). The informants include probands and their parents and teachers.

Long-term Objectives: The long-term objectives are to identify the endophenotypes that are close to the biological expression of genes underlying ADHD, to determine the familial aggregation and its specificity regarding the components of ADHD, and neuropsychological deficit, and to identify the impact of ADHD on academic, psychiatric, family, and social outcomes; and to identify a cohort of families with ADHD for future neuroimaging, neurophysiological, and molecular genetic studies.


Condition
Attention Deficit Hyperactivity Disorder

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: A Follow-up, Family Study on Attention-deficit Hyperactivity Disorder

Resource links provided by NLM:


Further study details as provided by National Taiwan University Hospital:

Enrollment: 1800
Study Start Date: January 2005
Study Completion Date: December 2009
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   10 Years to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Community-based sample & children with ADHD and their families

Criteria

Inclusion Criteria:

  • Community-based sample for the development of several Chinese versions of instruments: SNAP-IV, SDQ, ASRI, and ASRS.
  • ADHD follow-up family studies (ADHD group): (1) that subjects either had the clinical diagnosis of DSM-IV ADHD, which was made by a full-time child psychiatrist at the first visit and following visits or by a child psychiatrist using the K-SADS-E as the second-stage case ascertainment at an epidemiological study; (2) the diagnoses of ADHD were made 3-6 years ago; (3) their ages range from 12 to 15 when we conduct study; (4) subjects have at least one sibling aged 6-18 and live with at least one biological parent; and (5) subjects and their family consent to participate in this study.
  • (control group)(1) that subjects were assessed either at a clinical setting or in an epidemiological study same as to those in the exposed group 6 years ago; (2) their ages range from 12 to 15 when we conduct study; (3) subjects have at least one sibling aged 6-18 and live with at least one biological parent; and (4) subjects and their family consent to participate in this study.

Exclusion Criteria:

  • The subjects, including those who in the exposed and unexposed groups, will be excluded from the study if they currently meet criteria or have a history of the following condition as defined by DSM-IV: Schizophrenia, Schizoaffective Disorder, Organic Psychosis, Mental Retardation, or Pervasive Developmental Disorder. Moreover, the subjects will be excluded from the unexposed group if have a history of the following condition as defined by DSM-IV: ADHD, ODD, or CD in addition to the above exclusion criteria.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00417781

Locations
Taiwan
National Taiwan Univeristy Hospital
Taipei, Taiwan, 10002
Sponsors and Collaborators
National Taiwan University Hospital
National Health Research Institutes, Taiwan
Investigators
Principal Investigator: Susan Shur-Fen Gau, MD, PhD National Taiwan University Hospital & College of Medicine
  More Information

No publications provided by National Taiwan University Hospital

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00417781     History of Changes
Other Study ID Numbers: 9361700470, NHRI-EX94-9407PC, NHRI-EX95-9407PC, NHRI-EX96-9607PC, NHRI-EX97-9707PC, NHRI-EX98-9507PC
Study First Received: December 31, 2006
Last Updated: November 12, 2012
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
ADHD, adolescence, family study, endophenotype, outcome

Additional relevant MeSH terms:
Attention Deficit Disorder with Hyperactivity
Hyperkinesis
Attention Deficit and Disruptive Behavior Disorders
Mental Disorders Diagnosed in Childhood
Mental Disorders
Dyskinesias
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms

ClinicalTrials.gov processed this record on July 20, 2014