Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

This study has been withdrawn prior to enrollment.
Sponsor:
Collaborator:
Swiss National Science Foundation
Information provided by:
University Hospital Inselspital, Berne
ClinicalTrials.gov Identifier:
NCT00412672
First received: December 15, 2006
Last updated: October 22, 2010
Last verified: October 2010
  Purpose

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.


Condition
Myocardial Infarction

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction

Resource links provided by NLM:


Further study details as provided by University Hospital Inselspital, Berne:

Estimated Enrollment: 105
Study Start Date: July 2010
Detailed Description:

The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.

It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.

The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index (CPI) as obtained by transthoracic MCE.

Extent of LV remodelling, i.e., LV dilatation as assessed by serial assessment of LV dimension by LV angiogram and/or echocardiography, respectively.

  Eligibility

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients with acute myocardial infarction undergoing primary PCI as reperfusion therapy of a totally occluded coronary artery.

Criteria

Inclusion Criteria:

  • Patients with acute myocardial infarction with electrocardiographic criterion and/or typical history of angina pectoris and planned revascularisation according to the acute myocardial infarction disease management guidelines of the University Hospital Bern. Including both, patients undergoing primary PCI and patients referred for rescue PCI after failed thrombolytic therapy
  • Patients > 18 years old of either sex
  • Patients who have given informed consent to the study

Exclusion Criteria:

  • Patients unable to give informed consent e.g. because of mechanical ventilation
  • Patients with cardiogenic shock
  • Patients with myocardial infarction secondary to occlusion of a recently revascularized vessel (subacute stent thrombosis)
  • Patients with severe arrhythmias
  • Patients whose door-to-balloon time exceeds 120 minutes
  • Pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00412672

Locations
Switzerland
University Hospital Inselspital
Bern, Switzerland, 3010
Sponsors and Collaborators
University Hospital Inselspital, Berne
Swiss National Science Foundation
Investigators
Principal Investigator: Christian Seiler, Prof. University Hospital Bern, Switzerland
  More Information

No publications provided

Responsible Party: Christian Seiler, MD, Professor and Co-Chairman of Cardiology, Department of Cardiology, University Hospital, CH-3010 Bern, Switzerland
ClinicalTrials.gov Identifier: NCT00412672     History of Changes
Other Study ID Numbers: 37/01
Study First Received: December 15, 2006
Last Updated: October 22, 2010
Health Authority: Switzerland: Swissmedic

Keywords provided by University Hospital Inselspital, Berne:
Myocardial infarction
contrast echocardiography
collateral circulation

Additional relevant MeSH terms:
Infarction
Myocardial Infarction
Ischemia
Pathologic Processes
Necrosis
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on September 18, 2014