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Insulin Resistance and Hypertensive Disorders in Pregnancy

This study has been completed.
Sponsor:
Information provided by:
University of Messina
ClinicalTrials.gov Identifier:
NCT00412230
First received: December 15, 2006
Last updated: February 17, 2009
Last verified: February 2009
  Purpose

The purpose of this study is to determine whether insulin resistance might affect the pathogenesis of hypertensive disorders in pregnancy since midtrimester. Furthermore, markers of vascular and placental injuries, of oxidative stress and inflammation will be evaluated.


Condition
Hypertension in Pregnancy
Diabetes Mellitus in Pregnancy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: The Role of Insulin Resistance in Gestational Hypertension and in Preeclampsia.

Resource links provided by NLM:


Further study details as provided by University of Messina:

Estimated Enrollment: 100
Study Start Date: October 2006
Study Completion Date: June 2008
Groups/Cohorts
no treatment
2

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

pregnant outpatients

Criteria

Inclusion Criteria:

  • PCOS, BMI>/=30
  • previous pregnancy affected by hypertension or gestational diabetes
  • thrombophilia
  • Type I or II diabetes mellitus
  • autoimmune diseases
  • twin pregnancy
  • renal diseases
  • previous pre-eclampsia in relatives
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00412230

Locations
Italy
University Hospital
Messina, Italy, 98121
Sponsors and Collaborators
University of Messina
Investigators
Principal Investigator: Rosario D'Anna, Associate Professor University of Messina
  More Information

No publications provided

Responsible Party: Rosario D'Anna, University of Messina
ClinicalTrials.gov Identifier: NCT00412230     History of Changes
Other Study ID Numbers: 120254
Study First Received: December 15, 2006
Last Updated: February 17, 2009
Health Authority: Italy: Ministry of Health

Keywords provided by University of Messina:
Pre-eclampsia
Gestational diabetes
Insulin resistance
hypertension in pregnancy

Additional relevant MeSH terms:
Hypertension
Hypertension, Pregnancy-Induced
Pregnancy in Diabetics
Pregnancy Complications
Diabetes Mellitus
Insulin Resistance
Pre-Eclampsia
Cardiovascular Diseases
Endocrine System Diseases
Glucose Metabolism Disorders
Hyperinsulinism
Metabolic Diseases
Vascular Diseases
Insulin
Hypoglycemic Agents
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on November 25, 2014