Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

This study has been completed.
Sponsor:
Information provided by:
University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT00410111
First received: December 11, 2006
Last updated: October 15, 2008
Last verified: October 2008
  Purpose

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this condition have different patterns of cerebrovascular reactivity and whether it is possible to predict the development of septic encephalopathy from early measurements of cerebral perfusion or from the EEG. We will specifically test the hypotheses that septic encephalopathy may not be predicted by changes in the EEG, and that cerebrovascular autoregulation is not dysfunctional in septic encephalopathy.


Condition
Sepsis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Pilotstudy on Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Resource links provided by NLM:


Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment: 23
Study Start Date: January 2007
Study Completion Date: July 2007
  Eligibility

Ages Eligible for Study:   16 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients with sepsis, severe sepsis or septic shock admitted to an intensive care unit

Criteria

Inclusion Criteria:

  • Sepsis
  • Admission to ICU

Exclusion Criteria:

  • CNS infection
  • History of cerebrovascular disease
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00410111

Locations
Switzerland
Operative Intensivbehandlung, University of Basel Hospital
Basel, Switzerland, 4031
Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
Principal Investigator: Luzius A Steiner, MD PhD Department of Anesthesia, University of Basel Hospital, Basel, Switzerland
  More Information

No publications provided by University Hospital, Basel, Switzerland

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00410111     History of Changes
Other Study ID Numbers: EKBB 226/06
Study First Received: December 11, 2006
Last Updated: October 15, 2008
Health Authority: Switzerland: Federal Office of Public Health

Keywords provided by University Hospital, Basel, Switzerland:
sepsis
encephalopathy
cerebral perfusion
electroencephalogram

Additional relevant MeSH terms:
Sepsis
Brain Diseases
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Central Nervous System Diseases
Nervous System Diseases

ClinicalTrials.gov processed this record on August 21, 2014