Recombinant Measles Virus Vaccine Therapy and Oncolytic Virus Therapy in Treating Patients With Progressive, Recurrent, or Refractory Ovarian Epithelial Cancer or Primary Peritoneal Cancer

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Mayo Clinic
ClinicalTrials.gov Identifier:
NCT00408590
First received: December 6, 2006
Last updated: July 14, 2014
Last verified: July 2014
  Purpose

RATIONALE: A gene-modified virus may be able to kill tumor cells without damaging normal cells.

PURPOSE: This phase I trial is studying the side effects and best dose of an attenuated oncolytic measles virus therapy and oncolytic virus therapy in treating patients with progressive, recurrent, or refractory ovarian epithelial cancer or primary peritoneal cancer (measles virus vaccine therapy study closed as of 06/02/2008).


Condition Intervention Phase
Ovarian Cancer
Primary Peritoneal Cavity Cancer
Biological: carcinoembryonic antigen-expressing measles virus
Biological: oncolytic measles virus encoding thyroidal sodium iodide symporter
Genetic: reverse transcriptase-polymerase chain reaction
Other: laboratory biomarker analysis
Phase 1

Study Type: Interventional
Study Design: Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase I Trial of Intraperitoneal Administration of a) a CEA-Expressing Derivative, and b) a NIS-Expressing Derivative Manufactured From a Genetically Engineered Strain of Measles Virus in Patients With Recurrent Ovarian Cancer

Resource links provided by NLM:


Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • Number of toxicity incidents [ Designated as safety issue: Yes ]
  • Maximum-tolerated dose [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Number of responses (complete and partial, stable and progressive disease) [ Designated as safety issue: No ]
  • CA-125 levels [ Designated as safety issue: No ]
  • Time to progression [ Designated as safety issue: No ]
  • Laboratory correlates [ Designated as safety issue: No ]

Estimated Enrollment: 46
Study Start Date: April 2004
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

  • Determine the safety and toxicity of recombinant carcinoembryonic antigen (CEA)-expressing measles virus (MV-CEA) and oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) in patients with progressive, recurrent, or refractory ovarian epithelial or primary peritoneal cavity cancer ( MV-CEA closed as of 06/02/2008).
  • Determine the maximum-tolerated dose of MV-CEA and MV-NIS in these patients ( MV-CEA closed as of 06/02/2008).
  • Characterize viral gene expression at each dose level as manifested by CEA titers in these patients.
  • Assess viremia, viral replication, and measles virus shedding or persistence after study therapy.
  • Determine humoral and cellular immune response to the injected virus in these patients.
  • Assess, preliminarily, the antitumor efficacy of this therapy, by assessing CA-125 levels, radiographic response, and time to progression, in these patients.
  • Determine the time course of viral gene expression and virus elimination and biodistribution of virally infected cells at various time points after infection with MV-NIS using single photon emission computed tomography (SPECT/CT) imaging.
  • Assess viremia, viral replication, and measles virus shedding/persistence following intraperitoneal administration of MV-NIS.

OUTLINE: This is a dose-escalation study.

Patients receive recombinant carcinoembryonic antigen-expressing measles virus (MV-CEA) or oncolytic measles virus encoding thyroidal sodium iodide symporter (MV-NIS) intraperitoneally over 30 minutes on day 1. Treatment repeats every 28 days for up to 6 courses in the absence of disease progression or unacceptable toxicity ( MV-CEA closed as of 06/02/2008).

Cohorts of 3-6 patients receive escalating doses of MV-CEA until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity ( MV-CEA closed as of 06/02/2008).

Peripheral blood mononuclear cells are collected at baseline and periodically during and after treatment to assess viremia. Throat gargle and urine specimens are assessed periodically during course 1 for viral shedding by reverse transcriptase-polymerase chain reaction (RT-PCR). Peritoneal aspirate is tested at baseline and periodically during treatment for viral replication by RT-PCR, co-culture with Vero cells, and measles virus N-specific mRNA in situ hybridization.

Patients may undergo single photon emission computed tomography (SPECT/CT) imaging at baseline and periodically during study.

After completion of study therapy, patients are followed periodically for up to 15 years.

PROJECTED ACCRUAL: A total of 46 patients will be accrued for this study.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion criteria:

  • Age ≥ 18 years.
  • Must have persistent, recurrent or progressive ovarian cancer or primary peritoneal cancer after prior treatment with platinum and taxol compounds. Histologic confirmation of the original primary tumor is required. Prior bilateral oophorectomy is required.
  • Patients with the following histologic epithelial cell types are eligible: Serous adenocarcinoma, endometroid adenocarcinoma, mucinous adenocarcinoma, undifferentiated carcinoma, clear cell adenocarcinoma, mixed epithelial carcinoma, transitional cell carcinoma, malignant Brenner's Tumor, or adenocarcinoma NOS
  • The following laboratory values obtained ≤7 days prior to registration:

    • ANC ≥ 1500/μL
    • PLT ≥ 100,000/μL
    • Total bilirubin ≤ upper normal limit
    • AST ≤ 2 x ULN
    • Creatinine ≤ 1.5 x ULN
    • Hgb ≥ 9.0 g/dL
  • Ability to provide informed consent.
  • Willingness to return to Mayo Clinic Rochester for follow-up.
  • Life expectancy ≥ 12 weeks.
  • Must have anti-measles immunity as demonstrated by serum IgG anti-measles antibody levels of ≥ 20.0 EU/ml as determined by Enzyme Immunoassay (Diamedix, FL).
  • Must have normal serum CEA levels (<5 mg/ml) both at the time of study entry and in any prior testing. (NOTE: Not applicable for the MV-NIS cohort.)
  • Willingness to provide all biologic specimens as required by the protocol.
  • Measurable disease by exam or CT scan, or, for patients with CA-125 elevation or with microscopic residual but without measurable disease on imaging, willingness to undergo laparoscopy for evaluation of treatment effect if no radiographic progression after 6 treatment cycles.
  • CD4 count ≥200/μL or ≥15% of peripheral blood lymphocytes

Exclusion criteria:

  • Epithelial tumors of low malignant potential, stromal tumors, and germ cell tumors of the ovary.
  • Known standard therapy for the patient's disease that is potentially curative or definitely capable of extending life expectancy. Subjects will be excluded if this is their first relapse and they have recurred >6 mo from completion of primary (adjuvant) chemotherapy.
  • ECOG performance status (PS) 3 or 4.
  • Active infection ≤5 days prior to registration.
  • History of tuberculosis or history of PPD positivity.
  • History of other malignancy ≤5 years except for non-melanoma skin cancer or carcinoma in situ of the cervix.
  • Any of the following prior therapies:

    • Chemotherapy ≤ 3 weeks prior to study entry
    • Immunotherapy ≤ 4 weeks prior to study entry
    • Biologic therapy ≤ 4 weeks prior to study entry
    • Extensive abdominal surgery if it includes enterotomy(ies) <3 weeks prior to study entry. This criterion does not apply to placement of the peritoneal port-a-cath or lysis of adhesions at the time of study entry.
    • Any viral or gene therapy prior to study entry
  • Failure to fully recover from acute, reversible effects of prior chemotherapy regardless of interval since last treatment.
  • New York Heart Association classification III or IV, known symptomatic coronary artery disease, or symptoms of coronary artery disease on systems review, or known cardiac arrhythmias (atrial fibrillation or SVT).
  • Requiring blood product support.
  • CNS metastases or seizure disorder.
  • HIV-positive test result, or history of other immunodeficiency.
  • History of organ transplantation.
  • History of chronic hepatitis B or C.
  • Other concurrent chemotherapy, immunotherapy, radiotherapy, or any ancillary therapy considered investigational (utilized for a non-FDA-approved indication and in the context of a research investigation).
  • Any concurrent medications which could interfere with the trial.
  • Intra-abdominal disease > 8 cm in diameter at the time of registration, intrahepatic disease, or disease beyond the abdominal cavity.
  • Treatment with oral/systemic corticosteroids, with the exception of topical or inhaled steroids.
  • Exposure to household contacts ≤15 months old or household contact with known immunodeficiency.
  • Allergy to measles vaccine or history of severe reaction to prior measles vaccination.
  • Allergy to iodine. This does not include reactions to intravenous contrast materials.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00408590

Locations
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Study Chair: Evanthia Galanis, MD Mayo Clinic
  More Information

Additional Information:
No publications provided

Responsible Party: Mayo Clinic
ClinicalTrials.gov Identifier: NCT00408590     History of Changes
Other Study ID Numbers: CDR0000515008, P30CA015083, MC0117, 1260-03, NCI-2009-01199
Study First Received: December 6, 2006
Last Updated: July 14, 2014
Health Authority: United States: Food and Drug Administration

Keywords provided by Mayo Clinic:
ovarian clear cell cystadenocarcinoma
ovarian endometrioid adenocarcinoma
primary peritoneal cavity cancer
ovarian mixed epithelial carcinoma
ovarian mucinous cystadenocarcinoma
ovarian serous cystadenocarcinoma
ovarian undifferentiated adenocarcinoma
recurrent ovarian epithelial cancer
Brenner tumor

Additional relevant MeSH terms:
Measles
Ovarian Neoplasms
Peritoneal Neoplasms
Neoplasms, Glandular and Epithelial
Morbillivirus Infections
Paramyxoviridae Infections
Mononegavirales Infections
RNA Virus Infections
Virus Diseases
Endocrine Gland Neoplasms
Neoplasms by Site
Neoplasms
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Abdominal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Peritoneal Diseases
Neoplasms by Histologic Type

ClinicalTrials.gov processed this record on August 26, 2014