Phase I Study of P276-00 in Patients With Advanced Refractory Neoplasms
This study has been terminated.
(The decision to terminate this study after 202 mg/m2 cohort was taken as MTD achieved in other study at 185 mg/m2)
Information provided by:
Piramal Enterprises Limited
First received: December 4, 2006
Last updated: December 31, 2008
Last verified: December 2008
P276-00 is a molecule derived from Rohitukine, which through pre clinical assays was identified as a selective Cdk4-D1 and Cdk1-B inhibitor.The inhibition of these Cdks causes cell cycle arrest between the G1-S transition thus blocking the cell cycle events at an early stage of development. It therefore has the potential for being efficacious with lesser side effects.
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
||An Open Label Multicentric Phase 1 Study of Selective Cyclin Dependent Kinase Inhibitor P276-00 in Patients With Advanced Refractory Neoplasms
Primary Outcome Measures:
- Safety assessment by Laboratory investigations (Hematology,Biochemistry, urinalysis), ECG, Holter monitoring,Physical examination [ Time Frame: 2 years ] [ Designated as safety issue: Yes ]
Secondary Outcome Measures:
- Tumor measurements,Pharmacokinetics, MALDI- TOF to study plasma peptide pattern [ Time Frame: 2 years ] [ Designated as safety issue: No ]
| Study Start Date:
| Study Completion Date:
| Primary Completion Date:
||August 2008 (Final data collection date for primary outcome measure)
Potent Cyclin dependent kinase (cdk) cdk4 D1, cdk1 B and cdk9 T inhibitor
|Ages Eligible for Study:
||18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
- Patients must have histologically and/ or cytologically confirmed malignancy that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective.
- Patients of either sex, of all races and ethnic groups, and > 18 years of age.
- ECOG (Eastern Cooperative Oncology Group) performance status ≤ 2 .
- Patients with life expectancy of at least 4 months.
Patients must have normal organ and marrow function as defined below:
- Hemoglobin ≥10 gm/dL
- absolute neutrophil count ≥ 1,500/mL
- platelets ≥ 100,000/mL
- total bilirubin within normal institutional limits
- AST/ALT ≤ 2.5 X institutional upper limit of normal (ULN)
- creatinine within 1.5 times the upper normal institutional limits
- The effects of P276-00 on the developing human foetus are unknown. For this reason women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) for the duration of the study during the duration of study participation and for at least 4 weeks after withdrawal from the study.
- Women who are nursing should not be included into the study
- Concomitant medications for diabetes, hypertension, pain relief and any other co-existing conditions, except cancer, are permitted when the patient is on study medication. There should be no change in the dosage of these medications in the 2 weeks prior to day 1 of cycle 1, with the exception of dosages for pain relief medication. Changes in the dose of anti-emetics and diuretics may be made provided they will not interfere with probable adverse effects of investigational product.
- Ability to understand and the willingness to sign a written informed consent document.
- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study (date of consent); or patients who have not recovered from adverse events (except grade 1 toxicities) due to agents administered more than 4 weeks earlier.
- Patients having received any other investigational agents within 4 weeks prior to the date of consent and patients who have not recovered completely from the side effects of the earlier investigational agent.
- Patients with known brain metastases should be excluded from this clinical trial.
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to P276-00.
- Patients having history of myocardial infarction or uncontrolled cardiac dysfunction during the previous 6 months.
- Patients having diarrhea requiring anti-diarrheal therapy.
- Patients having coagulopathy requiring anticoagulation.
- Patients with uncontrolled but stable intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.
- Women who are pregnant or nursing. P276-00 may have the potential for teratogenic or abortifacient effects. Since there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with P276-00, breastfeeding should be discontinued if the mother is to be treated with P276-00.
- Patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy. Therefore, HIV-positive patients are excluded from the study.
- Patients requiring the use of concomitant medications that prolong the QT/QTc interval and/or are known to cause Torsades de Pointes (TdP)
Please refer to this study by its ClinicalTrials.gov identifier: NCT00408018
|Nizam's Institute of Medicai Sciences
|Hyderabaad, Andhra Pradesh, India, 500082 |
|Hyderabad, Andhra Pradesh, India |
|Tata Memorial Hospital
|Mumbai, Maharashtra, India, 400012 |
Piramal Enterprises Limited
||Purvish M parikh, MD, DNB, PhD
||Tata Memorial Hospital
||Raghunadharao D, MD, DM
||Nizam's Institute of Medical Sciences
||Ravikumar Saxena, MD
No publications provided
||Dr Himanshu Parikh, Piramal Life Sciences Limited
History of Changes
|Other Study ID Numbers:
|Study First Received:
||December 4, 2006
||December 31, 2008
||India: Ministry of Health
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on March 06, 2014
Cyclin-Dependent Kinase Inhibitor Proteins
Protein Kinase Inhibitors
Molecular Mechanisms of Pharmacological Action