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Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies

This study has been completed.
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by (Responsible Party):
National Taiwan University Hospital
ClinicalTrials.gov Identifier:
NCT00407628
First received: December 3, 2006
Last updated: July 4, 2013
Last verified: January 2013
  Purpose

To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.


Condition
Stroke

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • clinical assessments, included balance, motor, walking,ADL, will be obtained for tests performed on D7, D30 and D90 [ Time Frame: D30, D90 and D180 post stroke onset ] [ Designated as safety issue: No ]

Enrollment: 24
Study Start Date: August 2006
Study Completion Date: July 2009
Primary Completion Date: June 2009 (Final data collection date for primary outcome measure)
Detailed Description:

Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (Falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (Wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.

  Eligibility

Ages Eligible for Study:   30 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

stroke patients

Criteria

Inclusion Criteria:

  • between 30 to 80 years old
  • diagnosis of the first-time onset of stroke as confirmed by imaging studies
  • within 30 days post onset University Hospital
  • brain lesions mainly involving either the cortical primary motor cortex (M1) area or confined to the subcortical (M1 spared)
  • No neurological or orthopedic problems which would affect their lower extremity function
  • no contraindications for MRI studies

Exclusion Criteria:

  • medically unstable
  • unable to communicate with the experimenters
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00407628

Locations
China, Taiwan
School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University
Taipei, Taiwan, China
Sponsors and Collaborators
National Taiwan University Hospital
National Science Council, Taiwan
Investigators
Study Chair: Pei-Fang Tang, PhD National Taiwan University Hospital
  More Information

No publications provided

Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT00407628     History of Changes
Other Study ID Numbers: 9561703031, NSC95-2314-B-002-238-MY3
Study First Received: December 3, 2006
Last Updated: July 4, 2013
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
Stroke
Diffusion spectrum tractography
Functional MRI (fMRI)
Lower extremity

Additional relevant MeSH terms:
Cerebral Infarction
Stroke
Brain Diseases
Brain Infarction
Brain Ischemia
Cardiovascular Diseases
Central Nervous System Diseases
Cerebrovascular Disorders
Nervous System Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on November 25, 2014