Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies
Recruitment status was Recruiting
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Purpose
To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.
| Condition | Intervention |
|---|---|
|
Stroke |
Behavioral: Electrical stimulation |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Open Label Primary Purpose: Diagnostic |
| Official Title: | Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies |
- Diffusion spectrum tractography on D7, D30 and D90
- clinical assessments, included balance, motor, walking,ADL, will be obtained for tests performed on D7, D30 and D90
| Estimated Enrollment: | 24 |
| Study Start Date: | August 2006 |
| Estimated Study Completion Date: | July 2009 |
Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (Falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (Wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.
Eligibility| Ages Eligible for Study: | 30 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- between 30 to 80 years old
- diagnosis of the first-time onset of stroke as confirmed by imaging studies
- within 30 days post onset University Hospital
- brain lesions mainly involving either the cortical primary motor cortex (M1) area or confined to the subcortical (M1 spared)
- No neurological or orthopedic problems which would affect their lower extremity function
- no contraindications for MRI studies
Exclusion Criteria:
- medically unstable
- unable to communicate with the experimenters
Contacts and Locations| Contact: Pei-Fang Tang, PhD | +886-2-3322-8128 | pftang@ntu.edu.tw |
| China, Taiwan | |
| School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University | Recruiting |
| Taipei, Taiwan, China | |
| Contact: Pei-Fang Tang, PhD +886-2-3322-8128 pftang@ntu.edu.tw | |
| Study Chair: | Pei-Fang Tang, PhD | National Taiwan University Hospital |
More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00407628 History of Changes |
| Other Study ID Numbers: | 9561703031, NSC95-2314-B-002-238-MY3 |
| Study First Received: | December 3, 2006 |
| Last Updated: | December 3, 2006 |
| Health Authority: | Taiwan: Department of Health |
Keywords provided by National Taiwan University Hospital:
|
Stroke Diffusion spectrum tractography Functional MRI (fMRI) Lower extremity |
Additional relevant MeSH terms:
|
Stroke Cerebral Infarction Cerebrovascular Disorders Brain Diseases Central Nervous System Diseases |
Nervous System Diseases Vascular Diseases Cardiovascular Diseases Brain Infarction Brain Ischemia |
ClinicalTrials.gov processed this record on June 13, 2013