Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

This study is currently recruiting participants.

Verified by Hadassah Medical Organization, November 2007

First Received: September 28, 2006 Last Updated: May 12, 2008 History of Changes

Sponsor:	Hadassah Medical Organization
Information provided by:	Hadassah Medical Organization
ClinicalTrials.gov Identifier:	NCT00382369

Purpose

Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.

Condition
Vocal Cord Paralysis

Study Type:	Observational
Study Design:	Family-Based, Prospective
Official Title:	Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Resource links provided by NLM:

MedlinePlus related topics: Nuclear Scans Paralysis

U.S. FDA Resources

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

DNA prepared from blood

Estimated Enrollment:	60
Study Start Date:	May 2005
Estimated Study Completion Date:	December 2007

Detailed Description:

In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.

Eligibility

Ages Eligible for Study:	10 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Families suffering of familial vocal cord paralysis

Criteria

Inclusion Criteria:

members of families suffering of familial vocal cord paralysis

Exclusion Criteria:

none

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00382369

Contacts

Contact: Eitan Kerem, MD

972-2-5844430

kerem@hadassah.org.il

Locations

Israel
Hadassah-Hebrew University Medical Center, Mt Scopus	Recruiting
Jerusalem, Israel, 24035
Contact: Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il
Contact: Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Sub-Investigator: Ariela Simon, MD

Sponsors and Collaborators

Hadassah Medical Organization

Investigators

Study Director:	Eitan Kerem, MD	Hadassah MO
Principal Investigator:	Batsheva Kerem, PhD	Hebrew University Jerusalem

More Information

Publications:

Manaligod JM, Skaggs J, Smith RJ. Localization of the gene for familial laryngeal abductor paralysis to chromosome 6q16. Arch Otolaryngol Head Neck Surg. 2001 Aug;127(8):913-7.

Responsible Party:	Hadassah Medical Organization ( Prof Eitan Kerem )
Study ID Numbers:	VOCALCORD-HMO-CTIL
Study First Received:	September 28, 2006
Last Updated:	May 12, 2008
ClinicalTrials.gov Identifier:	NCT00382369 History of Changes
Health Authority:	Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:

familial vocal cord paralysis
genetic screening

Additional relevant MeSH terms:

Vagus Nerve Diseases
Paralysis
Signs and Symptoms
Otorhinolaryngologic Diseases
Respiratory Tract Diseases

Nervous System Diseases
Vocal Cord Paralysis
Neurologic Manifestations
Cranial Nerve Diseases
Laryngeal Diseases

ClinicalTrials.gov processed this record on November 30, 2009