Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2 - Full Text View

Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

This study has been completed.

Sponsored by:	Danish Headache Center
Information provided by:	Danish Headache Center
ClinicalTrials.gov Identifier:	NCT00374530

Purpose

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Condition	Intervention
Headache Migraine	Drug: PGE2

Genetics Home Reference related topics:

familial hemiplegic migraine

MedlinePlus related topics:

Headache Migraine

ChemIDplus related topics:

Dinoprostone

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Randomized, Double-Blind, Placebo Control, Crossover Assignment

Official Title:	Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:

Headache

Secondary Outcome Measures:

rCBF, blood flow, diameter of STA/RA, HR, BP

Estimated Enrollment:	12
Study Start Date:	August 2006

Eligibility

Ages Eligible for Study:	18 Years to 40 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

Healthy volunteers

Exclusion Criteria:

Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00374530

Locations


Denmark
	Danish Headache Center
	Glostrup, Denmark, DK-2600

Sponsors and Collaborators

Danish Headache Center

Investigators


Principal Investigator:	Troels Wienecke, MD	Danish Headache Center

More Information

Study ID Numbers:	KA-20060026
First Received:	September 8, 2006
Last Updated:	July 31, 2007
ClinicalTrials.gov Identifier:	NCT00374530
Health Authority:	Denmark: Ethics Committee

Study placed in the following topic categories:

Signs and Symptoms

Dinoprostone

Migraine Disorders

Headache

Central Nervous System Diseases

Neurologic Manifestations

Headache Disorders, Primary

Pain

Brain Diseases

Headache Disorders

Additional relevant MeSH terms:

Nervous System Diseases

ClinicalTrials.gov processed this record on September 05, 2008