Anorexia in Children With Burn Injury and the Reactions of the Immune and Endocrine Systems

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2007 by Sheba Medical Center.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Sheba Medical Center
ClinicalTrials.gov Identifier:
NCT00369876
First received: August 29, 2006
Last updated: January 23, 2007
Last verified: January 2007
  Purpose

Anorexia in children with burn injury is a common phenomenon. The study is searching for the origin of the anorexia in those children. The study correlates between the level peptides of the immune and the endocrine systems and the length of the anorexia.


Condition Phase
Burns
Anorexia
Phase 1

Study Type: Observational
Study Design: Observational Model: Defined Population
Time Perspective: Longitudinal
Official Title: The Association Between Anorexia and the Level of Hormones, Cytokines and Neuroendocrine Peptides in Children After Burn Injury

Resource links provided by NLM:


Further study details as provided by Sheba Medical Center:

Estimated Enrollment: 10
Study Start Date: August 2004
Estimated Study Completion Date: July 2006
Detailed Description:

Burn injury lead to hypermetabolic set to heal the damaged tissue.Burn healing uses high energy consumption and as consequence is highly There is a huge activation of the endocrine system and immune system resulting a proinflamtory status.

The nutrition component has an important role in the burn healing process by reducing the healing time and also in the quality of the scar tissue. It's been observed that many burn injury patients are suffering from anorexia. Since we know pro-inflammatory status modulate satiety rises the question is there a correlation between the level peptides of the immune and the endocrine systems to anorexia in children with burn injury.

Catecholamines serum concentrations rise following a burn injury. These hormones have an important role in determining the basal metabolic rate (BMR). During the healing process the levels of growth hormone (GH) and Insulin like growth factor I (IGF-1) are reduced. Previous studies show a correlation between these lower levels and Interleukins and cytokines such as Tumor Necrosis Factor (TNF) Interleukin-6 (IL-6). Additional hormones, which are relevant, are cortisol and insulin. Cortisol levels are very high after severe burn injuries for a long period. insulin sensitivity state also has an important role in the healing process.

TNFa and IL-6, which are inflammatory factors, found to have significantly elevated serum concentrations during the healing process. They are also known to be reducers to GH sensitivity and causes anorexia.

This study will show the connection between the immune and the endocrine systems to the burn healing process and anorexia by examining the level of hormones, interleukins and neuropeptide during the burn healing. our goal is to try and improve the treatment in children with burn injury by nutritional or drug intervention.

  Eligibility

Ages Eligible for Study:   6 Months to 16 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age below 16 years
  • Abilty to feed yourself during hospitalization
  • Gaining consciousness during hospitalization
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00369876

Locations
Israel
Sheba medical center
Tel-Hashomer, Israel, 52621
Sponsors and Collaborators
Sheba Medical Center
Investigators
Principal Investigator: Omer bAR-yOSEF, dR. Sheba Medical Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00369876     History of Changes
Other Study ID Numbers: SHEBA-04-3392-OB-CTIL
Study First Received: August 29, 2006
Last Updated: January 23, 2007
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Sheba Medical Center:
Burns
Anorexia
Neuropeptide
Leptin
Adiponectin
Gherlin

Additional relevant MeSH terms:
Anorexia
Burns
Wounds and Injuries
Signs and Symptoms, Digestive
Signs and Symptoms

ClinicalTrials.gov processed this record on July 26, 2014