Inclusion Criteria:

• Vocal skills necessary to complete test procedures reliably.
• Voice complaints and/or other symptoms suggestive of reflux laryngitis
• Signed informed consent
• At least 18 years of age.
• Complete medical history and physical examination within 30 days prior to initiation of the study drug.
• Laryngoscopy documenting laryngeal pathology compatible with moderate to severe reflux laryngitis (> grade 3 arytenoid erythema) within 30 days of initiation of the study drug.
• Gastroesophageal reflux confirmed by 24-hour (a minimum of 16 hours required for inclusion) pH impedance monitor.
• Ambulatory outpatient status.
• If female, a negative pregnancy test at the screening visit or either: i) surgically sterilized (bilateral tubal ligation or hysterectomy), or ii) at least 1 year post-menopausal, or iii) using acceptable methods of contraception in the presence of childbearing potential.

Exclusion Criteria:

• Concurrent laryngeal disease, if such disease or its treatment would interfere with evaluation of study results. For example, patients with mass lesions such as laryngeal cysts or laryngeal carcinoma will be excluded. Patients with acute laryngeal infections or acute laryngeal allergies will be excluded until these conditions have been resolved; but they may be considered for inclusion thereafter.
• Any upper gastroenterological or esophageal surgery except simple over-sewing of a perforated ulcer.
• Active substance abuse.
• Tobacco use.
• Known hypersensitivity or allergy to any protein pump inhibitor.
• ALT (SGPT) or AST (SGOT) greater than 2 times the upper limit of normal.
• Renal impairment (serum creatinine > 2.0 mg/dl).
• Any clinically significant, unstable medical condition.
• Use of any proton pump inhibitor within 7 days prior to 24-hour pH impedance monitoring or baseline strobovideolaryngoscopy, or use of H2 receptor antagonist during the 48 hours prior to 24-hour pH impedance monitoring or baseline strobovideolaryngoscopy.
• Use of an investigational drug or participation in an investigational study, within 30 days prior to starting study drug.
• Previous participation in this study.
• Pregnant women.
• Women breast feeding infants.
• Inability or refusal to follow directions.
• Open label sub-study has same inclusion and exclusion criteria, with exception that subjects should have: 1) Clinical diagnosis of non-acid reflux, with less than 5 episodes of proximal acid reflux, and 2) Symptoms and signs consistent with gastroesophageal reflux.