Blood Collection From Individuals With Lung Disease for Genetic Studies
This is a research study where researchers are collecting blood to evaluate the genetic characteristics of individuals with chronic lung diseases, including asthma, COPD (chronic obstructive pulmonary disease), interstitial lung disease, cystic fibrosis, and lung cancer.
Interstitial Lung Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Collection of Blood for Gene Expression/Genomic Studies in Individuals With Chronic Lung Disease|
In this study, a small amount of blood for extraction of DNA for the study of the genetic basis of lung disease will be obtained from each subject. The collected blood (cells and serum) will be used for genetic testing in studies relating to the genetic material and/or gene expression, and/or studies of proteins or other substances in serum (the liquid portion of the blood after it has been allowed to clot). Because these latter protein studies will occur at a future date, the serum will be stored for use in these studies.
|Study Start Date:||September 2005|
|Estimated Study Completion Date:||September 2013|
|Estimated Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
1: Lung Disease
Individuals with at least one of the following: (1)symptoms consistent with pulmonary disease; (2) chest X-ray consistent with lung disease; (3) pulmonary function tests consistent with lung disease; (4) lung biopsy consistent with lung disease; (5) family history of lung disease; (6) patients with diseases of organs with known association with lung disease; (7) individuals suspected of history of lung diseased based on history and/or physical examination
2: Normal Controls
Individuals without a history of lung disease
The investigators hope to be able to identify an association between a genetic make-up in the blood samples and the risks of developing a particular lung disease, or severity of a lung disease. The findings of this study might be important to develop future preventative methods and potential treatments for the management of lung disease. The investigators aim to collect blood samples from 300 people with lung disease and 300 controls over 5 years.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00362739
|Contact: Charleen Hollmann, PhD, MPA, RNfirstname.lastname@example.org|
|United States, New York|
|New York Presbyterian Hospital -- Weill Cornell Medical College of Cornell University||Recruiting|
|New York, New York, United States, 10021|
|Principal Investigator: Ronald G Crystal, MD|
|Principal Investigator:||Ronald G Crystal, MD||The New York Presbyterian Hospital -- Weill Medical College of Cornell University|