Development of a Noninvasive Method of Evaluation of Pulmonary Inflammation in the Condensates of Exhaled Air
The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD, asthma, tobacco exposure. Three proteases will be analyzed, i.e. elastase, proteinase 3 and cathepsin G. Results in the condensates will be compared to those obtained in sputum.
Condensate of Exhaled Air
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Development of a Noninvasive Method of Evaluation of the Pulmonary Inflammation in the Condensates of Exhaled Air|
|Study Start Date:||July 2006|
|Estimated Study Completion Date:||July 2008|
5 groups of 20 individuals each: group 1 CF, group 2 COPD, group 3 asthma, group 4 tobacco exposure, group 5 control subjects.
Collection of exhaled condensates in all subjects and of sputum in subjects belonging to groups 1 and 2.
Clinical examination and PFTs in all patients.
|Service de Pneumologie et EFR CHRU Tours|
|Tours, France, 37044|
|Principal Investigator:||DIOT Patrice, Pr||service de Pneumologie et EFR CHRU Tours|