Amyloid Plaque and Tangle Imaging in Aging and Dementia
Amyloid senile plaques (SPs) and neurofibrillary tangles (NFTs) are neuropathological hallmarks of Alzheimer's disease (AD) that also accumulate in key brain regions in association with normal aging. This project will expand an established program in early detection and prevention of AD designed (1) to identify presymptomatic persons most likely to benefit from early intervention and (2) to provide an objective, noninvasive means to monitor therapeutic trials.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Amyloid Plaque and Tangle Imaging in Aging and Dementia|
|Study Start Date:||September 2005|
|Study Completion Date:||May 2010|
|Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
Mild Cognitive Impairment
A total of 194 volunteers will be recruited for this 2-year study. Participants will receive a baseline clinical and imaging evaluation and one follow-up evaluation two years later. These evaluations will include clinical and neuropsychological assessments, structural MRI and/or PET scans. Additional scans and scanning procedures will be performed on a subset of participants and participant visits, including serotonin density levels.
|United States, California|
|Jane & Terry Semel Institute for Neuroscience & Human Behavior|
|Los Angeles, California, United States, 90024|
|Principal Investigator:||Gary W. Small, MD||University of California, Los Angeles, Neuropsychiatric Institute|