Failure of Implantation After Recurrent Embryo Transfers

This study has been completed.
Information provided by:
UMC Utrecht Identifier:
First received: July 12, 2006
Last updated: May 28, 2008
Last verified: April 2007

We will investigate maternal and embryonic factors in women with recurrent implantation failure, undergoing IVF/ ICSI treatment. Women who have not achieved a pregnancy after three embryo transfer procedures will undergo an endometrial biopsy during the window of implantation in a natural cycle. During the next treatment cycle we will aspirate endometrial secretion and perform a doppler ultrasound investigation of the a. uterina. Moreover, we will investigate the cytokine expression from the transferred embryo from the culture medium.


Study Type: Observational
Official Title: Recurrent Embryo Implantation Failure in Women Undergoing IVF/ ICSI; an Investigation of the Intra-Uterine Environment During the Window of Implantation

Resource links provided by NLM:

Further study details as provided by UMC Utrecht:

Estimated Enrollment: 80
Study Start Date: July 2006
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
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Ages Eligible for Study:   18 Years to 37 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Women who have not achieved a pregnancy, despite 3 subsequent embryo transfers, of which only one is allowed to be a transfer of a cryo-thawed embryo. A chemical pregnancy or E.U.G. will not be regarded as a pregnancy. An abortion will be regarded as a pregnancy.

Exclusion Criteria:

  • women older than 37 years.
  Contacts and Locations
Please refer to this study by its identifier: NCT00351481

University Medical Center Utrecht
Utrecht, Netherlands, 3584CX
Sponsors and Collaborators
UMC Utrecht
Study Chair: Nick Macklon, Professor UMC Utrecht
  More Information

Publications: Identifier: NCT00351481     History of Changes
Other Study ID Numbers: FIRE-study
Study First Received: July 12, 2006
Last Updated: May 28, 2008
Health Authority: Netherlands: Medical Ethics Review Committee (METC)

Keywords provided by UMC Utrecht:
endometrial receptivity
embryo implantation
recurrent implantation failure

Additional relevant MeSH terms:
Genital Diseases, Male
Genital Diseases, Female processed this record on April 21, 2014