Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Measuring Time Windows in Patients With Schizophrenia and Healthy Controls

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2014 by University Hospital, Strasbourg, France
Sponsor:
Collaborators:
Institut National de la Santé Et de la Recherche Médicale, France
France: Centre National de la Recherche Scientifique
Faculté de Médecine de Strasbourg
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT00350805
First received: July 10, 2006
Last updated: August 26, 2014
Last verified: August 2014
  Purpose

Abnormalities in the ability to distinguish events in time may have a great impact on everyday life. The main objective of the study is to evaluate the magnitude of the temporal windows in schizophrenia, i.e. the time interval during which two events are perceived as synchronous. The investigators test the hypothesis that these temporal windows are enlarged, and check the relationship between this impairment and disorganization symptoms, in order to explore the link between this cognitive impairment and clinical symptoms. They explore also the neurobiological bases of the impairment by means of electroencephalogram (EEG) recordings. Event-related potentials (N50) will reveal whether or not the coding of the stimuli has the same temporal characteristics in patients and controls. The distribution and amplitude of oscillatory activities will be analyzed as a function of the synchronous or asynchronous response of the subject, thus allowing to explore the links between synchrony perception and neuronal synchronization phenomena.


Condition Intervention
Schizophrenia
Procedure: EEG

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Relating the 'Experienced Present' With the Mechanisms of Neuronal Function: A Comparative Study in Patients With Schizophrenia and Healthy Controls Using Psychophysical and Neurophysiological Methods

Resource links provided by NLM:


Further study details as provided by University Hospital, Strasbourg, France:

Estimated Enrollment: 228
Study Start Date: September 2005
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Healthy volunteers Procedure: EEG
One 20 minutes session
Patients Procedure: EEG
One 20 minutes session

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Primary care clinic, residents of Strasbourg

Criteria

Inclusion Criteria:

  • Patients with schizophrenia (DSM-IV criteria)
  • Healthy controls matched with patients on age, sex and education level
  • Age between 18 and 50
  • Informed consent signed
  • No severe somatic illness
  • No invalidating sensory disease
  • No drug abuse, as defined by DSM-IV criteria
  • No general anesthesia in the past 3 months
  • No intake of drug affecting the CNS, except for patients
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00350805

Contacts
Contact: Anne GIERSCH, MD 33.3.88.11.64.71 giersch@alsace.u-strasbg.fr

Locations
France
Service de Psychiatrie Adulte & INSERM U841, Hôpital Albert Chenevier et Henri Mondor (AP-HP) Recruiting
Créteil, France, 94000
Contact: Franck SCHURHOFF, MD    33.3.1.49.81.30.50    schurhof@ext.jussieu.fr   
Principal Investigator: Franck SCHURHOFF, MD         
Sub-Investigator: Andrei SZOKE, MD         
INSERM U666 - Département de Psychiatrie - Hôpitaux Universitaires de Strasbourg Recruiting
Strasbourg, France, 67091
Contact: Anne GIERSCH, MD    33.3.88.11.64.71    giersch@alsace.u-strasbg.fr   
Principal Investigator: Anne GIERSCH, MD         
Sub-Investigator: Pierre VIDAILHET, MD         
Sub-Investigator: Philippe SONNTAG, MD         
Sub-Investigator: Marie-Agathe ZIMMERMANN, MD         
Sub-Investigator: Daniel GRUCKER, MD         
Sub-Investigator: Jack FOUCHER, MD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
Institut National de la Santé Et de la Recherche Médicale, France
France: Centre National de la Recherche Scientifique
Faculté de Médecine de Strasbourg
Investigators
Principal Investigator: Anne GIERSCH, MD Institut National de la Santé Et de la Recherche Médicale, France
  More Information

No publications provided

Responsible Party: University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier: NCT00350805     History of Changes
Other Study ID Numbers: 3494
Study First Received: July 10, 2006
Last Updated: August 26, 2014
Health Authority: France: Ministry of Health

Keywords provided by University Hospital, Strasbourg, France:
Schizophrenia
Time perception
Cortical synchronization
Electroencephalography

Additional relevant MeSH terms:
Schizophrenia
Mental Disorders
Schizophrenia and Disorders with Psychotic Features

ClinicalTrials.gov processed this record on November 20, 2014