• Concentrations of antibodies against vaccine pneumococcal serotypes [ Time Frame: 1 month after the administration of the primary or the full vaccination course with GSK Biologicals' 10-valent pneumococcal conjugate vaccine ]
  

• Opsonophagocytic activity against vaccine pneumococcal serotypes [ Time Frame: 1 month after the administration of the primary or the full vaccination course, with GSK Biologicals' 10-valent pneumococcal conjugate vaccine ]
  
• Concentrations of antibodies against cross-reactive pneumococcal serotypes [ Time Frame: 1 month after the administration of the primary or the full vaccination course, with GSK Biologicals' 10-valent pneumococcal conjugate vaccine ]
  
• Opsonophagocytic activity against cross-reactive pneumococcal serotypes. [ Time Frame: 1 month after the administration of the primary or the full vaccination course, with GSK Biologicals' 10-valent pneumococcal conjugate vaccine ]
  
• Concentrations of antibodies against protein D. [ Time Frame: 1 month after the administration of the primary or the full vaccination course, with GSK Biologicals' 10-valent pneumococcal conjugate vaccine ]
  
• Concentrations of antibodies against vaccine pneumococcal serotypes. [ Time Frame: Before and one month after the booster dose with GSK Biologicals' 10-valent pneumococcal conjugate vaccine for the < 6 Mo and 7-11 Mo groups ]
  
• Opsonophagocytic activity against vaccine pneumococcal serotypes [ Time Frame: Before and one month after the booster dose with GSK Biologicals' 10-valent pneumococcal conjugate vaccine for the < 6 Mo and 7-11 Mo groups ]
  
• Concentrations of antibodies against cross-reactive pneumococcal serotypes [ Time Frame: Before and one month after the booster dose with GSK Biologicals' 10-valent pneumococcal conjugate vaccine for the < 6 Mo and 7-11 Mo groups ]
  
• Opsonophagocytic activity against cross-reactive pneumococcal serotypes [ Time Frame: Before and one month after the booster dose with GSK Biologicals' 10-valent pneumococcal conjugate vaccine for the < 6 Mo and 7-11 Mo groups ]
  
• Concentrations of antibodies against protein D. [ Time Frame: Before and one month after the booster dose with GSK Biologicals' 10-valent pneumococcal conjugate vaccine for the < 6 Mo and 7-11 Mo groups ]
  
• Anti-diphtheria and anti-tetanus toxoids, anti-PRP, anti-pertussis, anti-HBs antibody concentrations and anti-polio type 1, 2 and 3 titres. [ Time Frame: 1 month after the administration of the primary vaccination course, before & 1 mth after the booster dose with GSK Biologicals' DTPa-IPV/Hib vaccine when co-administered with GSK Biologicals' 10-valent pneumococcal conjugate vaccine in the < 6 Mo gr ]
  
• Booster vaccine response to pertussis [ Time Frame: One month after the booster dose in the < 6 Mo group ]
  
• Occurrence of solicited local symptoms [ Time Frame: Within 4 days after each vaccination. ]
  
• Occurrence of solicited general symptoms [ Time Frame: Within 4 days after each vaccination. ]
  
• Occurrence of unsolicited adverse events [ Time Frame: Within 31 days after each vaccination. ]
  
• Occurrence of serious adverse events. [ Time Frame: Throughout the whole study period ]
  

The Protocol Posting has been updated in order to comply with the FDA Amendment Act, Sep 2007

Inclusion Criteria:

• Male or female between, and including

  • 9-12 weeks of age at the time of first vaccination for the <6 Mo group.
  • 7-11 months of age at the time of first vaccination for the 7-11 Mo group.
  • 12-23 months of age at the time of first vaccination for the 12-23 Mo group.
  • 24 months to 5 years at the time of first vaccination for the >= 24 Mo group.
• Subjects for whom the investigator believes that their parents/guardians can and will comply with the requirements of the protocol
• Written informed consent obtained from the parent or guardian of the subject.
• Free of obvious health problems as established by medical history and clinical examination before entering into the study.
• Born after a gestation period between 36 and 42 weeks.

Exclusion Criteria:

• Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine within 30 days preceding the first dose of study vaccine, or planned use during the entire study period for each age-group.
• Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the first vaccine dose.
• Planned administration/ administration of a vaccine not foreseen by the study protocol during the period starting one month before and ending one month after each dose of vaccine(s).
• Previous vaccination against S. pneumoniae.
• History of allergic disease or reactions likely to be exacerbated by any component of the vaccines.
• History of seizures (this criterion does not apply to subjects who have had a single, uncomplicated febrile convulsion in the past) or neurological disease.
• Acute disease at the time of enrolment.
• Any confirmed or suspected immunosuppressive or immunodeficient condition based on medical history and physical examination
• A family history of congenital or hereditary immunodeficiency.
• Major congenital defects or serious chronic illness.
• Administration of immunoglobulins and/or any blood products since birth or planned administration during the entire study period.