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| Sponsored by: |
National Institute of Environmental Health Sciences (NIEHS) |
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00342329 |
Purpose
The purpose of this study is to examine hormonal and environmental risk factors (and possible gene-environmental interactions) involved in the etiology of lupus nephritis. Our study will focus on exposures to occupational and environmental agents that have been linked to the development of systemic lupus erythematosus (SLE) or renal disease (e.g., silica dust, smoking). We will also assess potential gene environment interactions. We will examine these exposures in 100 patients with renal biopsy with documented proliferative or membraneous nephritis. We will compare exposures in the lupus nephritis patients to lupus patients who do not have nephritis and to normal controls who have participated in the Carolina Lupus Study. One hundred lupus nephritis patients (age 18 years or older, of both genders and all races) will be identified through the Glomerular Disease Collaborative Network (GDCN) Nephropathology database and participating nephrologists at the Medical University of South Carolina, Duke University Medical Center and the East Carolina Medical School.
| Condition |
|
Lupus Nephritis |
| MedlinePlus related topics: | Occupational Health Smoking Smoking and Youth |
| Study Type: | Observational |
| Official Title: | Lupus Nephritis: Role of Environmental and Occupational Exposures |
| Estimated Enrollment: | 0 |
| Study Start Date: | April 2001 |
| Estimated Study Completion Date: | March 2007 |
The purpose of this study is to examine hormonal and environmental risk factors (and possible gene-environmental interactions) involved in the etiology of lupus nephritis. Our study will focus on exposures to occupational and environmental agents that have been linked to the development of systemic lupus erythematosus (SLE) or renal disease (e.g., silica dust, smoking). We will also assess potential gene environment interactions. We will examine these exposures in 100 patients with renal biopsy with documented proliferative or membraneous nephritis. We will compare exposures in the lupus nephritis patients to lupus patients who do not have nephritis and to normal controls who have participated in the Carolina Lupus Study. One hundred lupus nephritis patients (age 18 years or older, of both genders and all races) will be identified through the Glomerular Disease Collaborative Network (GDCN) Nephropathology database and participating nephrologists at the Medical University of South Carolina, Duke University Medical Center and the East Carolina Medical School.
Eligibility
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Have renal biopsy proven Lupus Nephritis (with the biopsy-based diagnosis date no earlier than January 1, 1995).
Reside within designated counties of eastern North Carolina and South Carolina.
Contacts and Locations| United States, North Carolina | |||||
| University of North Carolina | |||||
| Chapel Hill, North Carolina, United States, 27599-7030 | |||||
| NIEHS, Research Triangle Park | |||||
| Research Triangle Park, North Carolina, United States, 27709 | |||||
More Information
| Study ID Numbers: | 999901154, 01-E-N154 |
| First Received: | June 19, 2006 |
| Last Updated: | March 5, 2008 |
| ClinicalTrials.gov Identifier: | NCT00342329 |
| Health Authority: | United States: Federal Government |
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