Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

This study is currently recruiting participants. (see Contacts and Locations)
Verified May 2014 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00340626
First received: June 19, 2006
Last updated: May 28, 2014
Last verified: May 2014
  Purpose

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.


Condition
Hereditary Oral Clefts

Study Type: Observational
Official Title: Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Primary Outcome Measures:
  • Genetic risk factor for oral clefts

Estimated Enrollment: 1000
Study Start Date: June 1997
Detailed Description:

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:

  1. A cluster of 2 or more affected first degree relatives, such as a parent and two offspring or 2 siblings, or
  2. The occurrence of oral clefts in each of 2 generations in either the proband's paternal or maternal lineages.

EXCLUSION CRITERIA:

Families with syndromic forms of oral clefts.

Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00340626

Contacts
Contact: Joan Bailey-Wilson, Ph.D. (443) 740-2921 jebw@nhgri.nih.gov

Locations
Syrian Arab Republic
IBN Al Nafees Hospital Recruiting
Damascus, Syrian Arab Republic
Sponsors and Collaborators
Investigators
Principal Investigator: Joan Bailey-Wilson, Ph.D. National Human Genome Research Institute (NHGRI)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00340626     History of Changes
Other Study ID Numbers: 999997035, OH97-HG-N035
Study First Received: June 19, 2006
Last Updated: May 28, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Whole Genome Sequencing
Cleft Palate

ClinicalTrials.gov processed this record on August 28, 2014