Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair

This study is not yet open for participant recruitment.

Verified by Denver Research Institute, December 2004

First Received: June 13, 2006 No Changes Posted

Sponsor:	Denver Research Institute
Information provided by:	Denver Research Institute
ClinicalTrials.gov Identifier:	NCT00336726

Purpose

Traumatic Brain Injury (TBI) is a neurologic disorder cuased by physical trauma to the brain. Neuroendocrine abnormalities in these patients have been reported, including central hypogonadism within hours of the insult and eventual recovery of the hypothalamic-pituitary-gonadal axis with recovery of cognitive function to baseline. This pilot study will measure hormonal level of neuroendocine function at the time of TBI and various time points during recovery.

Condition
Traumatic Brain Injury

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study

Resource links provided by NLM:

MedlinePlus related topics: Traumatic Brain Injury

U.S. FDA Resources

Eligibility

Ages Eligible for Study:	21 Years to 65 Years
Genders Eligible for Study:	Male
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Male subjects having had a recent traumatic brain injury.

Exclusion Criteria:

Currently receivng sex steroids, glucocorticoids, or have an inability to complete the neurobehavioral assessment.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00336726

Sponsors and Collaborators

Denver Research Institute

Investigators

Principal Investigator:

Margaret E Wierman, MD

Dept. of Veterans Affairs/University of Colorado HSC

More Information

No publications provided

Study ID Numbers:	GR-735
Study First Received:	June 13, 2006
Last Updated:	June 13, 2006
ClinicalTrials.gov Identifier:	NCT00336726 History of Changes
Health Authority:	United States: Institutional Review Board

Additional relevant MeSH terms:

Craniocerebral Trauma
Nervous System Diseases
Wounds and Injuries
Disorders of Environmental Origin

Central Nervous System Diseases
Trauma, Nervous System
Brain Diseases
Brain Injuries

ClinicalTrials.gov processed this record on November 20, 2009