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| Sponsor: | University Hospital, Clermont-Ferrand |
|---|---|
| Collaborators: |
University Hospital, Limoges Institut National de la Recherche Agronomique |
| Information provided by: | University Hospital, Clermont-Ferrand |
| ClinicalTrials.gov Identifier: | NCT00331812 |
Purpose
In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor. One of the implicated factors is the increase of resting energy expenditure (REE) which can be found in about 50 % of ALS patients. The origin of this hypermetabolism is currently unknown but could be located in the mitochondria. In fact, some studies have found mitochondrial abnormalities and the existence of an oxidative stress. Thus, the aim of this study is to characterize the mitochondrial abnormalities and the oxidant/antioxidant status of ALS patients and to determine their relationship with the metabolic status, hypermetabolism or normometabolism. Three groups of patients will be studied : 20 hypermetabolic ALS patients, 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex.
| Condition | Intervention |
|---|---|
|
Amyotrophic Lateral Sclerosis |
Procedure: Mitochondrial functions and oxidative stress |
| Study Type: | Observational |
| Study Design: | Prospective |
| Official Title: | Study of Mitochondrial Functions and Oxidative Stress in ALS Patients. |
| Estimated Enrollment: | 40 |
| Study Start Date: | February 2006 |
| Estimated Study Completion Date: | February 2008 |
In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor. One of the implicated factors is the increase of resting energy expenditure (REE) which can be found in about 50 % of ALS patients. The origin of this hypermetabolism is currently unknown but could be located in the mitochondria. In fact, some studies have found mitochondrial abnormalities and the existence of an oxidative stress. Thus, the aim of this study is to characterize the mitochondrial abnormalities and the oxidant/antioxidant status of ALS patients and to determine their relationship with the metabolic status, hypermetabolism or normometabolism. Three groups of patients will be studied : 20 hypermetabolic ALS patients, 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex.
Eligibility| Ages Eligible for Study: | 30 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Three groups of patients will be studied : 20 hypermetabolic ALS patients, 20 normometabolic ALS patients and 20 healthy volunteers paired for age and sex.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Corinne Bouteloup, Dr | (+33) 04 73 75 05 04 | cbouteloup@chu-clermontferrand.fr |
| France, Auvergne | |
| Clermont-Ferrand University Hospital | Recruiting |
| Clermont-Ferrand, Auvergne, France, 63000 | |
| Principal Investigator: | Corinne Bouteloup, Dr | University Hospital, Clermont-Ferrand |
More Information
| Responsible Party: | CHU Clermont-Ferrand ( Dr Corinne BOUTELOUP ) |
| Study ID Numbers: | CHU63-0007 |
| Study First Received: | May 23, 2006 |
| Last Updated: | July 10, 2008 |
| ClinicalTrials.gov Identifier: | NCT00331812 History of Changes |
| Health Authority: | France: Ministry of Health |
|
Hypermetabolism Mitochondrial abnormalities Oxidant/antioxidant status |
|
Pathologic Processes Neuromuscular Diseases Spinal Cord Diseases Amyotrophic Lateral Sclerosis Nervous System Diseases |
Central Nervous System Diseases Sclerosis Neurodegenerative Diseases Motor Neuron Disease |