Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine
Recruitment status was Recruiting
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Purpose
24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.
| Condition | Intervention |
|---|---|
|
Hemorrhoids Fissure in Ano |
Drug: Administration of 0,7 mg of atropine Device: Measurement of skin conductance with Pain detector |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Factorial Assignment Masking: Open Label Primary Purpose: Prevention |
- Number of skin conductance fluctuations
| Estimated Enrollment: | 24 |
| Study Start Date: | January 2006 |
Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.
Study hypothesis: SC is not influenced by i.v. administration of atropine.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Patients in ASA-group 1-2
- Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
- informed consent
- BMI <30
Exclusion Criteria:
- Patients using any medication known to influence the autonomous nervous system
- Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
- BMI >30
- Pregnancy
Contacts and Locations| Contact: Hanne Storm, PhD | +47 23074398 | hanne.storm@medisin.uio.no |
| Norway | |
| Ulleval University Hospital | Recruiting |
| Oslo, Norway, 0407 | |
| Contact: Hanne Storm, PhD +47 23074398 hanne.storm@medisin.uio.no | |
| Study Director: | Hanne Storm, PhD | Rikshospitalet University Hospital |
More Information
No publications provided
| Responsible Party: | Hanne Storm MD.PhD, Rikshospitalet, UIO |
| ClinicalTrials.gov Identifier: | NCT00328900 History of Changes |
| Other Study ID Numbers: | S-03113 |
| Study First Received: | May 22, 2006 |
| Last Updated: | May 31, 2012 |
| Health Authority: | Norway:National Committee for Medical and Health Research Ethics |
Keywords provided by Rikshospitalet University Hospital:
|
Galvanic skin response Anesthesia Atropine |
Additional relevant MeSH terms:
|
Hemorrhoids Fissure in Ano Anus Diseases Rectal Diseases Intestinal Diseases Gastrointestinal Diseases Digestive System Diseases Vascular Diseases Cardiovascular Diseases Anesthetics Atropine Central Nervous System Depressants Physiological Effects of Drugs Pharmacologic Actions Central Nervous System Agents |
Therapeutic Uses Adjuvants, Anesthesia Anti-Arrhythmia Agents Cardiovascular Agents Bronchodilator Agents Autonomic Agents Peripheral Nervous System Agents Anti-Asthmatic Agents Respiratory System Agents Mydriatics Parasympatholytics Muscarinic Antagonists Cholinergic Antagonists Cholinergic Agents Neurotransmitter Agents |
ClinicalTrials.gov processed this record on June 17, 2013