Measurement of Stress During Anesthesia With ”Pain Detector” on Patients Receiving Atropine

This study is currently recruiting participants.

Verified by Rikshospitalet University Hospital, April 2007

First Received: May 22, 2006 Last Updated: April 19, 2007 History of Changes

Sponsor:	Rikshospitalet University Hospital
Information provided by:	Rikshospitalet University Hospital
ClinicalTrials.gov Identifier:	NCT00328900

Purpose

24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.

Condition	Intervention
Hemorrhoids Fissure in Ano	Drug: Administration of 0,7 mg of atropine Device: Measurement of skin conductance with Pain detector

Study Type:	Interventional
Study Design:	Prevention, Randomized, Open Label, Uncontrolled, Factorial Assignment

Resource links provided by NLM:

MedlinePlus related topics: Anesthesia Hemorrhoids

Drug Information available for: Atropine Atropine sulfate

U.S. FDA Resources

Further study details as provided by Rikshospitalet University Hospital:

Primary Outcome Measures:

Number of skin conductance fluctuations

Estimated Enrollment:	24
Study Start Date:	January 2006

Detailed Description:

Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.

Study hypothesis: SC is not influenced by i.v. administration of atropine.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Patients in ASA-group 1-2
Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
informed consent
BMI <30

Exclusion Criteria:

Patients using any medication known to influence the autonomous nervous system
Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
BMI >30
Pregnancy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00328900

Contacts

Contact: Hanne Storm, PhD

+47 23074398

hanne.storm@medisin.uio.no

Locations

Norway
Ulleval University Hospital	Recruiting
Oslo, Norway, 0407
Contact: Hanne Storm, PhD +47 23074398 hanne.storm@medisin.uio.no

Sponsors and Collaborators

Rikshospitalet University Hospital

Investigators

Study Director:

Hanne Storm, PhD

Rikshospitalet University Hospital

More Information

No publications provided

Study ID Numbers:	S-03113
Study First Received:	May 22, 2006
Last Updated:	April 19, 2007
ClinicalTrials.gov Identifier:	NCT00328900 History of Changes
Health Authority:	Norway: The National Committees for Research Ethics in Norway

Keywords provided by Rikshospitalet University Hospital:

Galvanic skin response
Anesthesia
Atropine

Additional relevant MeSH terms:

Respiratory System Agents
Parasympatholytics
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Cholinergic Antagonists
Gastrointestinal Diseases
Physiological Effects of Drugs
Cholinergic Agents
Rectal Diseases
Fissure in Ano
Therapeutic Uses
Cardiovascular Diseases
Anti-Arrhythmia Agents
Vascular Diseases
Anti-Asthmatic Agents

Cardiovascular Agents
Intestinal Diseases
Pharmacologic Actions
Adjuvants, Anesthesia
Muscarinic Antagonists
Digestive System Diseases
Mydriatics
Autonomic Agents
Hemorrhoids
Peripheral Nervous System Agents
Central Nervous System Agents
Anus Diseases
Bronchodilator Agents
Atropine

ClinicalTrials.gov processed this record on November 27, 2009