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Relationship of Genes and Life Events to Blood Pressure

This study has been completed.
Sponsor:
Information provided by:
Sunnybrook Health Sciences Centre
ClinicalTrials.gov Identifier:
NCT00327431
First received: May 17, 2006
Last updated: May 21, 2008
Last verified: May 2008
History of Changes
  Purpose

Research suggests that blood pressure is influenced by both genetic and environmental factors. The goal of this study is to find genes that play a role in blood pressure and understand how they interact with life events (such as job stress) to influence blood pressure. We hypothesize that the gene for endothelin-1 is associated with increased blood pressure. Further, we predict that this genetic relationship is moderated by psychosocial stress factors, specifically job strain and marital cohesion.


Condition Intervention
Hypertension
Psychosocial Factors
 Genetic: Cheek swab samples for DNA

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Sunnybrook Health Sciences Centre:

Estimated Enrollment: 120
Study Start Date: November 2006
Study Completion Date: December 2007
  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Previous participation in a study of psychosocial stressors and blood pressure (Double Exposure Study) and agreement to participate in follow-up studies

Exclusion Criteria:

  • Withdrawal of consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00327431

Locations
Canada, Ontario
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Sponsors and Collaborators
Sunnybrook Health Sciences Centre
Investigators
Study Chair: Brian Baker, MB, ChB University of Toronto
Study Chair: Sheldon Tobe, MD Sunnybrook Health Sciences Centre
  More Information

Publications:

ClinicalTrials.gov Identifier: NCT00327431     History of Changes
Other Study ID Numbers: 1000009109
Study First Received: May 17, 2006
Last Updated: May 21, 2008
Health Authority: Canada: Ethics Review Committee

Keywords provided by Sunnybrook Health Sciences Centre:
Hypertension
Blood Pressure
Psychosocial Factors

Additional relevant MeSH terms:
Hypertension
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on May 19, 2013