Effect of Bright Light on Sex Hormones and Ovulation in Humans

This study has been completed.
Sponsor:
Information provided by:
Russian Academy of Medical Sciences
ClinicalTrials.gov Identifier:
NCT00327366
First received: May 17, 2006
Last updated: October 18, 2009
Last verified: October 2009
  Purpose

The study investigated whether bright artificial light may influence menstrual cycle and ovulation conclusively, and what underlying hormonal changes for this effect are.


Condition Intervention
Anovulation
Procedure: Light therapy

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Basic Science

Further study details as provided by Russian Academy of Medical Sciences:

Enrollment: 27
Study Start Date: September 2003
Study Completion Date: April 2006
Detailed Description:

Several studies have shown a shortening of the menstrual cycle following light therapy in women with abnormally long menstrual cycles or with winter depression, which suggests that bright light may influence sex hormones and ovulation. The study was designed to investigate this possibility. Twenty-two women with slightly lengthened menstrual cycles and without clinically evident endocrine abnormalities completed a study lasting for two menstrual cycles separated by an off-protocol episode of at least 1 menstrual cycle. Bright light therapy was administered for a week at home during one experimental cycle, and dim light during another cycle (placebo-controlled, crossover, counter-balanced order). Daytime blood sampling and ultrasound scan were performed before and after a week of light therapy, on the ~7th and 14th days after menstruation onset. Ultrasound examination was repeated further to document ovulation. Serum was assayed for thyroid-stimulating hormone, prolactin, luteinizing hormone, follicle-stimulating hormone, and estradiol. The preliminary results were reported at the SLTBR meeting in June, 2005.

  Eligibility

Ages Eligible for Study:   19 Years to 40 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Age 19-40 years
  • Mean menstrual cycle 28-38 days
  • Good general health
  • Generally normal sleep-wake regimen
  • Motivated for free participation

Exclusion Criteria:

  • Low cooperation
  • Medications known to interfere with hormone release
  • Clinically evident endocrine abnormalities including the signs of
  • Hyperandrogenism
  • Travel over several time zones during two months prior the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00327366

Sponsors and Collaborators
Russian Academy of Medical Sciences
Investigators
Principal Investigator: Konstantin V. Danilenko, MD Institute of Internal Medicine SB RAMS
  More Information

No publications provided

Responsible Party: Outside In
ClinicalTrials.gov Identifier: NCT00327366     History of Changes
Other Study ID Numbers: M-s3
Study First Received: May 17, 2006
Last Updated: October 18, 2009
Health Authority: Russia: Ethics Committee

Keywords provided by Russian Academy of Medical Sciences:
Menstrual Cycle
Light Therapy
Sex Hormones
Ovulation

Additional relevant MeSH terms:
Anovulation
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Gonadal Disorders
Endocrine System Diseases

ClinicalTrials.gov processed this record on April 22, 2014