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A Neurocognitive Model of Anorexia Nervosa

This study is currently recruiting participants.
Verified December 2012 by New York State Psychiatric Institute
Sponsor:
Collaborators:
Klarman Family Foundation
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
New York State Psychiatric Institute
ClinicalTrials.gov Identifier:
NCT00325520
First received: May 12, 2006
Last updated: December 13, 2012
Last verified: December 2012
History of Changes
  Purpose

The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.


Condition
Anorexia Nervosa

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Neurocognitive Model of Anorexia Nervosa

Resource links provided by NLM:

MedlinePlus related topics: Eating Disorders
U.S. FDA Resources

Further study details as provided by New York State Psychiatric Institute:

Primary Outcome Measures:
  • Neuropsychological functioning [ Time Frame: pre- and post-treatment ] [ Designated as safety issue: No ]

Estimated Enrollment: 50
Study Start Date: May 2006
Estimated Study Completion Date: May 2014
Estimated Primary Completion Date: May 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Anorexia nervosa
Individuals with anorexia nervosa receiving inpatient treatment
Healthy controls

Detailed Description:

Patients with Anorexia Nervosa (AN) have extreme difficulty changing their eating behavior, even when they express desire for change. These behaviors seem to override all other potential responses, and can appear perseverative, or habitual. The purpose of this study is to investigate thought processes and neural mechanisms that may contribute to the development of habitual behaviors. The investigators hypothesize that patients with AN will perform differently than people without eating disorders on a series of neuropsychological tasks and will show different neural activation patterns in functional neuroimaging scans.

  Eligibility

Ages Eligible for Study:   16 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Patients with Anorexia Nervosa or Healthy Volunteers

Criteria

Inclusion:

  • DSM-IV-TR™ diagnosis of anorexia nervosa (restricting or binge-purge subtype), current or prior;
  • Age 16-45;
  • Inpatient on GCRU
  • Medically stable.

Exclusion:

  • Any other current major Axis I disorder (including current bulimia nervosa), except major depression;
  • History of concussion, seizure disorder, or other neurological illness;
  • History of learning disability;
  • Acute Suicidality

Healthy comparison group:

Inclusion:

  • No current or past psychiatric illness;
  • Age 16-45
  • No history of binge eating or vomiting;
  • Normal weight (80%-120% ideal body weight)

Exclusion:

  • Significant medical or neurologic illness(concussion, seizure disorder, learning disability, other neurological illness)
  • Current psychotropic medication or medications known to impact cognition

Additional Exclusion Criteria for fMRI:

  • Significant Claustrophobia
  • Pregnancy
  • Indwelling metallic object, non-removable metal jewelry, medicinal patch or recent metallic ink tattoo
  • For patients, current psychotropic medications (antidepressants for 2 week (prozac and antipsychotics for 4 weeks)
  • For patients, any other current Axis I diagnosis
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00325520

Contacts
Contact: Eating Disorders Clinic 212-543-5739

Locations
United States, New York
New York State Psychiatric Institute Recruiting
New York, New York, United States, 10032
Principal Investigator: Joanna Steinglass, MD            
Sponsors and Collaborators
New York State Psychiatric Institute
Klarman Family Foundation
National Institute of Mental Health (NIMH)
Investigators
Principal Investigator: Joanna Steinglass, MD New York State Psychiatric Institute
  More Information

No publications provided

Responsible Party: New York State Psychiatric Institute
ClinicalTrials.gov Identifier: NCT00325520     History of Changes
Other Study ID Numbers: #5984R, K23MH076195-01A2
Study First Received: May 12, 2006
Last Updated: December 13, 2012
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Anorexia
Anorexia Nervosa
Signs and Symptoms, Digestive
 Signs and Symptoms
Eating Disorders
Mental Disorders

ClinicalTrials.gov processed this record on May 23, 2013