Plasma Brain Natriuretic Peptide Levels in Pregnancy
To evaluate the maternal blood concentrations of brain natriuretic peptide (BNP) during the second and third trimesters of a normal pregnancy. We will attempt to define a normal range for pregnancy and any outliers that may serve as markers for abnormal cardiovascular physiology.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Plasma Brain Natriuretic Peptide Levels in Pregnancy|
|Study Start Date:||August 2006|
|Study Completion Date:||June 2008|
Healthy pregnant women, 18-40
The brain natriuretic peptide (BNP) is a useful marker for volume overload, increased filling pressures and stretching of the myocardium. The current literature contains limited and unreliable information regarding normal BNP values in pregnancy. After baseline echocardiogram to detect individuals with asymptomatic structural defects, the participants will submit to 3 blood draws during the second and third trimester and at delivery to determine normal pregnancy values.
|United States, Oklahoma|
|Oklahoma State University Center for Health Sciences|
|Tulsa, Oklahoma, United States, 74127|
|Study Chair:||Kimberly A Sorensen, DO||Oklahoma State University Center for Health Sciences|
|Principal Investigator:||John M Beal, DO||Oklahoma State University Center for Health Sciences|