Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient

The recruitment status of this study is unknown because the information has not been verified recently.
Verified August 2009 by Chinese University of Hong Kong.
Recruitment status was  Active, not recruiting
Sponsor:
Information provided by:
Chinese University of Hong Kong
ClinicalTrials.gov Identifier:
NCT00324181
First received: May 8, 2006
Last updated: August 3, 2009
Last verified: August 2009
  Purpose

It is suggested the pathogenesis of normal-tension glaucoma (NTG) involves vascular dysregulation. In the past studies, it is well documented that many physical problems related to vascular dysregulation, such as angina pectoris (Friedman M et al 1974; Russek HI et al 1976), migraine (Diener HC et al 1994), primary Raynaud's disease (Wagner HH et al 1993) and stroke (Gainotti G, et al, 2001; Hayee Ma et al 2001), are associated with a high risk of depressive illness. So, NTG, being a disease involving vascular dysregulation, is postulated to be associated with psychopathology.

Glaucoma increases after 40 year-old and the number of people over this age in Hong Kong is rapidly growing. However, we have no knowledge about the link between psychopathology and NTG in Hong Kong. The present study is sought to overcome the limitation in previous research and the goals of present study are:

  • To identify the prevalence of psychopathology of normal-tension glaucoma Hong Kong Chinese Out-patients attending a university-affiliated glaucoma clinic.
  • To determine whether there are any differences among NTG patients, patients with glaucoma other than NTG and control in terms of psychopathology and quality of life.

Designs:

Case-control study to compare among patients with normal-tension glaucoma (NTG), patients with glaucoma other than normal-tension glaucoma (OTNTG) and control in terms of psychopathology and quality of life


Condition
Glaucoma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Psychopathology of Normal-tension Glaucoma in Hong Kong Chinese Out-patient

Resource links provided by NLM:


Further study details as provided by Chinese University of Hong Kong:

Estimated Enrollment: 100
Study Start Date: June 2006
Estimated Study Completion Date: June 2010
Estimated Primary Completion Date: June 2010 (Final data collection date for primary outcome measure)
Detailed Description:

Patients with chronic medical illness have been shown to have higher rates of depression and other psychopathology (Kimmel PL et al, 1998; Amato L et al, 1996). Glaucoma is a chronic, progressive ophthalmologic disease. Treatment may involve the use of multiple medications and surgery. Despite therapy, many patients continue to worsen, and some may even lose vision. Because of this threat of potential loss of vision and the known depression-related side effects of some of topical glaucoma medication, particular beta-blocker (Cove-Smith JR et al, 1985), it can be necessary hypothesized that glaucoma patient may have an increased prevalence of depression and other psychopathology. It is also reasonable to apply similar hypothesis on the patients with normal-tension glaucoma.

Normal-tension glaucoma (NTG) is a type of open-angle glaucoma defined as an optic neuropathy with visual-field defects together normal distribution of intraocular pressure (<21 mmHg) over a period of twenty-four hour as well as normal chamber-angle anatomy (Levene RZ, 1980). NTG is associated with different vasospastic syndrome including higher incidence of migraine (Phelps CD et al, 1985), angina pectoris (Goldberg I et al, 1981), silent myocardial ischemia (Kaiser HJ et al, 1993) and ocular vasopasm (Flammer J et al, 1991; Flammer J et al 1987; Orgul S et al 1995). Such associated clinical characteristics suggest that the pathogenesis of NTG involves vascular dysregulation. In the past studies, it is well documented that many physical problems related to vascular dysregulation, such as angina pectoris (Friedman M et al 1974; Russek HI et al 1976), migraine (Diener HC et al 1994), primary Raynaud's disease (Wagner HH et al 1993) and stroke (Gainotti G, et al, 2001; Hayee Ma et al 2001), are associated with a high risk of depressive illness. So, NTG, being a disease involving vascular dysregulation, is postulated to be associated with psychopathology.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Glaucoma patients from a tertiary University Ophthalmic clinic setting

Criteria

Inclusion Criteria:

Inclusion criteria of patients (NTG and OTNTG):

  • Cantonese-speaking Chinese
  • Aged from 18 to 65
  • Attending university-affiliated glaucoma clinic from August, 2005 to June, 2006 with written consent Inclusion criteria of control
  • Those just receiving routine fundi examination without any ophthalmologic follow-up afterwards
  • Cantonese-speaking Chinese
  • Aged from 18 to 65
  • With written consent

Exclusion Criteria of cases:

Exclusion criteria:

  • Psychoses
  • Psychiatric condition warranting hospitalization Exclusion criteria of control
  • Previous or current ocular or general acute or chronic disease
  • Taking any medication
  • Psychoses
  • Psychiatric condition warranting hospitalization
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00324181

Locations
China
Department of Psychiatry, Kowloon Hospital, Hong Kong
Hong Kong, China
Sponsors and Collaborators
Chinese University of Hong Kong
Investigators
Principal Investigator: Karina Chan, MBChB, MRCPsych Department of Psychiatry, Kowloon Hospital, Hong Kong
Study Director: Dexter Leung, MBChB, FRCS Chinese University of Hong Kong
Study Director: Sing Lee, MD, MRCPsych Department of Psychiatry, CUHK
Study Chair: Dennis Lam, MD, FRCOphth Chinese University of Hong Kong
  More Information

No publications provided

Responsible Party: Dexter Yu-lung LEUNG/ Honorary Clinical Assistant Professor, DOVS, CUHK
ClinicalTrials.gov Identifier: NCT00324181     History of Changes
Other Study ID Numbers: CRE-2006.060
Study First Received: May 8, 2006
Last Updated: August 3, 2009
Health Authority: Hong Kong: Ethics Committee

Keywords provided by Chinese University of Hong Kong:
normal-tension glaucoma
psychopathology
Hong Kong

Additional relevant MeSH terms:
Glaucoma
Low Tension Glaucoma
Ocular Hypertension
Eye Diseases
Optic Nerve Diseases

ClinicalTrials.gov processed this record on August 25, 2014