Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone - Full Text View

Retrograde Intrarenal Stone Surgery - A Method of Treating the ESWL Resistant Kidney Stone

This study is ongoing, but not recruiting participants.

Sponsored by:	Fredericia Hosptial
Information provided by:	Fredericia Hosptial
ClinicalTrials.gov Identifier:	NCT00323843

Purpose

Is it possible to decrease the intrarenal pressure in the kidney during endoscopic management of kidney stone by topical administration of drugs? In order to secure fewer complications in ureteroscopic operations the pharmacological agent isoproterenol is tested on pigs and human to determine its potential of lowering intrarenal pressure.

Condition	Intervention	Phase
Kidney Stone Ureteroscopy	Drug: Isoproterenol	Phase II

ChemIDplus related topics:

Isoproterenol Isoproterenol hydrochloride Isoproterenol sulfate

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study

Official Title:	RIRS - A Method of Treating the ESWL Resistant Kidney Stone

Further study details as provided by Fredericia Hosptial:

Primary Outcome Measures:

Renal pelvic pressure

Secondary Outcome Measures:

Blood pressure
Pulse

Estimated Enrollment:	10
Study Start Date:	June 2006
Estimated Study Completion Date:	February 2007

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Indication for RIRS procedure
Age > 18 years
Normotensive
Capable of understanding information given

Exclusion Criteria:

Previous myocardiac infarct
Daily use of alpha- og beta- blocking medicine og calcium antagonists
Use of NSAID the last 2 days
Stone in the ureter
Declared
Known malignant disease in urinary tract
Bladder disease
Nephrostomies inserted
JJ-catheters inserted
Prisoners
Pregnant
Nursing mothers

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00323843

Locations


Denmark, Vejle Council
	Dpt. of Urology
	Fredericia, Vejle Council, Denmark, 7000

Sponsors and Collaborators

Fredericia Hosptial

Investigators


Principal Investigator:	Helene U Jung	Fredericia Hospital, Dpt. of Urology

More Information

Study ID Numbers:	2005-005972-34
First Received:	May 8, 2006
Last Updated:	January 29, 2007
ClinicalTrials.gov Identifier:	NCT00323843
Health Authority:	Denmark: Danish Medicines Agency; Denmark: Ethics Committee

Keywords provided by Fredericia Hosptial:

Kidney stone

ureteropyeloscopy

renal pelvic pressure

Study placed in the following topic categories:

Pathological Conditions, Anatomical

Urinary Calculi

Urologic Diseases

Urolithiasis

Kidney Diseases

Calculi

Nephrolithiasis

Isoproterenol

Kidney Calculi

Additional relevant MeSH terms:

Respiratory System Agents

Neurotransmitter Agents

Adrenergic beta-Agonists

Adrenergic Agents

Molecular Mechanisms of Pharmacological Action

Sympathomimetics

Cardiotonic Agents

Physiological Effects of Drugs

Anti-Asthmatic Agents

Cardiovascular Agents

Protective Agents

Adrenergic Agonists

Pharmacologic Actions

Autonomic Agents

Therapeutic Uses

Peripheral Nervous System Agents

Bronchodilator Agents

ClinicalTrials.gov processed this record on September 05, 2008