• Clinical response rate (PS improvement by ECOG score, analgesic dose reduction)
  
• Response Rate Recist (Uni-Dimensional) Criteria
  
• Progression free survival
  
• Median survival
  
• Overall survival
  
• Quality of life
  

• Tolerance and Safety NCI-CTC version 2
  

OBJECTIVES:

• The primary objective is to determine the effectiveness the chemotherapy combination in improving the experience of those with advanced pancreatic cancer in

  • Pain control and other aspects of quality of life
  • Reduction of the tumor size or stabilization of tumor growth
  • Progression free survival
  • Overall survival
• The secondary objective is to determine the safety of this chemotherapy combination by monitoring and the managing the potential side effects

DOSE REGIMEN OUTLINE: Paclitaxel 60mg/m2 IV weekly; Oxaliplatin 50mg/m2 IV weekly; Leucovorin 20 mg/m2 IV weekly, minimum of 40 mg; 5FU 425mg/m2 IV weekly; Weekly for 12 weeks; Calcium and magnesium 1gram each IV prior to and after Oxaliplatin therapy; Glutathione 1500mg/m2 prior to Oxaliplatin

DURATION OF STUDY PERIOD: Patient will continue study treatment until death, disease progression, unacceptable toxicity, patient refusal, or treatment delay greater than 3 weeks, 12 weeks initially, can than continue at discretion of investigator.

EXPECTED NUMBER OF PATIENTS: A total of 80 patients (40 second line of treatment and 40 third line or greater of treatment) will be enrolled for this study beginning in May 2006.

QUALITY OF LIFE: Quality of life will be assessed at baseline, each month of treatment and at the end of study therapy.

DISEASE CHARACTERISTICS

Patients with pathologically-proven pancreatic adenocarcinoma, who

1. are not candidate for surgery
2. are not candidate for radiation therapy and
3. have failed gemcitabine-based chemotherapy regimen

Gender Eligible for Study:

• Both

Prior Therapy:

• For advanced disease allowed as above;
• Oxaliplatin or 5-FU will be allowed but a subset analysis will be done for this group of patients;
• Tarceva and/or Erbitux allowed, but subset analysis will be done.

Allergies:

• No known allergy to one of the study drugs

PATIENT CHARACTERISTICS:

• No CNS metastases
• No peripheral neuropathy > grade 2
• ECOG Performance Status <=2
• Age ≤ 65
• No other serious concomitant illness
• Fully recovered from any prior therapy

Lower Age Limit:

• >18

Upper Age Limit:

• ≤ 65

Laboratory:

• ANC >1500
• Platelets >75,000
• Creatinine <=2.0

Other:

• For female patient of childbearing potential, neither pregnant nor breastfeeding, and under active contraception

Exclusion Criteria:

• Performance state >=3
• Uncontrolled serious concomitant disease
• Radiotherapy within the 6 weeks before Cycle 1‚ Day 1
• Surgery within the 2 weeks before Cycle 1‚ Day 1