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| Sponsored by: |
Mackay Memorial Hospital |
| Information provided by: | Mackay Memorial Hospital |
| ClinicalTrials.gov Identifier: | NCT00322959 |
Purpose
Tai-Chi-Chuan (TCC), a branch of traditional Chinese martial arts, has been widely practiced since the 17th century. Recent studies have shown that TCC can improve cardiorespiratory function, muscle strength, humoral and cellular immunity, metabolic response and mental control.
Cultured monocytes from blood or bone marrow can be triggered to differentiate to myeloid dendritic cells (DC). DCs are specialized leukocytes for presenting antigens to quiescent, naive, and memory T cells, and they play pivotal roles in the induction of cell-mediated as well as humoral immune responses in vivo. Mature DCs have a capacity for initiating immunity or tolerance, which depends on their activation state.
In this study we will investigate the effect of TCC on DC differentiation in the peripheral blood obtained from the healthy donors who take part with and without TCC exercise. The distribution of various DC sub-populations (myeloid DC and plasmacytoid cell) will be analyzed by detecting surface marker expression.
| Condition |
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Immunity |
| Study Type: | Observational |
| Study Design: | Case Control, Prospective |
| Official Title: | Effect of Tai-Chi-Chuan on Differentiation and Maturation of Human Dendritic Cells |
| Enrollment: | 20 |
| Study Start Date: | August 2004 |
| Study Completion Date: | November 2006 |
| Primary Completion Date: | November 2006 (Final data collection date for primary outcome measure) |
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Show Detailed Description |
Eligibility
| Ages Eligible for Study: | 25 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
TCC practitioner and Healthy subjects as controls
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Taiwan | |||||
| Department of Medical Research, Mackay Memorial Hospital | |||||
| Taipei, Taiwan, 104 | |||||
| Mackay Memorial Hospital |
| Principal Investigator: | Yu-Jen Chen, MD, PhD | Mackay Memorial Hospital |
More Information
| Responsible Party: | Mackay Memorial Hospital ( Yu-Jen Chen ) |
| Study ID Numbers: | MMH-I-S-056 |
| First Received: | May 5, 2006 |
| Last Updated: | September 19, 2008 |
| ClinicalTrials.gov Identifier: | NCT00322959 |
| Health Authority: | Taiwan: Institutional Review Board |
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