Prophylactic Effect of Memantine in Chronic Tension-Type Headache

This study has been completed.
Sponsor:
Information provided by:
Danish Headache Center
ClinicalTrials.gov Identifier:
NCT00315666
First received: April 18, 2006
Last updated: February 19, 2009
Last verified: February 2009
  Purpose

The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.


Condition Intervention Phase
Tension-Type Headache
Drug: memantine
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double-Blind
Primary Purpose: Treatment
Official Title: Prophylactic Effect of Memantine in Chronic Tension-Type Headache

Resource links provided by NLM:


Further study details as provided by Danish Headache Center:

Primary Outcome Measures:
  • Headache duration
  • Headache intensity

Secondary Outcome Measures:
  • Headache frequency
  • The use of simple analgesics
  • Side effects

Estimated Enrollment: 40
Study Start Date: May 2006
Study Completion Date: June 2007
Primary Completion Date: June 2007 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Chronic tension-type headache
  • Normal urine pH

Exclusion Criteria:

  • More than 1 migraine attack/month
  • Other major illnesses
  • Overuse of medicine/alcohol
  • Women not using AC
  • Pregnant/breast-feeding women
  • Allergy to memantine
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00315666

Locations
Denmark
Danish Headaches Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
Investigators
Principal Investigator: Lars Bendtsen, MD, PhD Danish Headaches Center, Dept. of Neurology, KAS Glostrup, DK-2600 Glostrup
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00315666     History of Changes
Other Study ID Numbers: 2006-000060-82, KA-20060021
Study First Received: April 18, 2006
Last Updated: February 19, 2009
Health Authority: Denmark: Danish Medicines Agency

Keywords provided by Danish Headache Center:
Chronic tension-type headache

Additional relevant MeSH terms:
Headache
Tension-Type Headache
Headache Disorders, Primary
Headache Disorders
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Brain Diseases
Central Nervous System Diseases
Memantine
Antiparkinson Agents
Anti-Dyskinesia Agents
Central Nervous System Agents
Therapeutic Uses
Pharmacologic Actions
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents

ClinicalTrials.gov processed this record on October 19, 2014