Prophylactic Effect of Memantine in Chronic Tension-Type Headache

This study has been completed.

First Received: April 18, 2006 Last Updated: February 19, 2009 History of Changes

Sponsored by:	Danish Headache Center
Information provided by:	Danish Headache Center
ClinicalTrials.gov Identifier:	NCT00315666

Purpose

The purpose of this study is to test whether memantine has a prophylactic effect on chronic tension-type headaches.

Condition	Intervention	Phase
Tension-Type Headache	Drug: memantine	Phase III

Study Type:	Interventional
Study Design:	Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study
Official Title:	Prophylactic Effect of Memantine in Chronic Tension-Type Headache

Resource links provided by NLM:

MedlinePlus related topics: Headache

Drug Information available for: Memantine Memantine hydrochloride

U.S. FDA Resources

Further study details as provided by Danish Headache Center:

Primary Outcome Measures:

Headache duration
Headache intensity

Secondary Outcome Measures:

Headache frequency
The use of simple analgesics
Side effects

Estimated Enrollment:	40
Study Start Date:	May 2006
Study Completion Date:	June 2007
Primary Completion Date:	June 2007 (Final data collection date for primary outcome measure)

Eligibility

Ages Eligible for Study:	18 Years to 65 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Chronic tension-type headache
Normal urine pH

Exclusion Criteria:

More than 1 migraine attack/month
Other major illnesses
Overuse of medicine/alcohol
Women not using AC
Pregnant/breast-feeding women
Allergy to memantine

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00315666

Locations

Denmark
Danish Headaches Center
Glostrup, Denmark, DK-2600

Sponsors and Collaborators

Danish Headache Center

Investigators

Principal Investigator:

Lars Bendtsen, MD, PhD

Danish Headaches Center, Dept. of Neurology, KAS Glostrup, DK-2600 Glostrup

More Information

No publications provided

Study ID Numbers:	2006-000060-82, KA-20060021
Study First Received:	April 18, 2006
Last Updated:	February 19, 2009
ClinicalTrials.gov Identifier:	NCT00315666 History of Changes
Health Authority:	Denmark: Danish Medicines Agency

Keywords provided by Danish Headache Center:

Chronic tension-type headache

Study placed in the following topic categories:

Excitatory Amino Acids
Neurotransmitter Agents
Tension-Type Headache
Central Nervous System Diseases
Pain
Headache Disorders, Primary
Brain Diseases

Headache Disorders
Signs and Symptoms
Dopamine
Headache
Neurologic Manifestations
Memantine
Dopamine Agents

Additional relevant MeSH terms:

Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Anti-Dyskinesia Agents
Tension-Type Headache
Physiological Effects of Drugs
Nervous System Diseases
Antiparkinson Agents
Central Nervous System Diseases
Excitatory Amino Acid Agents
Pain
Headache Disorders, Primary

Brain Diseases
Pharmacologic Actions
Headache Disorders
Signs and Symptoms
Therapeutic Uses
Headache
Neurologic Manifestations
Memantine
Dopamine Agents
Central Nervous System Agents
Excitatory Amino Acid Antagonists

ClinicalTrials.gov processed this record on July 02, 2009