Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease and/ or Hypertension

This study has been completed.
Sponsor:
Information provided by:
Regional Hospital Holstebro
ClinicalTrials.gov Identifier:
NCT00313430
First received: April 11, 2006
Last updated: February 28, 2010
Last verified: February 2010
  Purpose

The investigators want to test the hypothesis that patients with chronic renal disease have a poorer ability to preserve water after being thirsty and a poorer ability to excrete water after a load of fluid. They presume that these abilities become poorer when renal insufficiency progresses. The investigators further hypothesize that patients with hypertension also have a decreased ability to concentrate and dilute urine.


Condition
Renal Insufficiency, Chronic
Hypertension

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Urinary Concentration and Diluting Ability in Patients With Chronic Renal Disease or Hypertension

Resource links provided by NLM:


Further study details as provided by Regional Hospital Holstebro:

Enrollment: 50
Study Start Date: May 2004
Primary Completion Date: March 2008 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Sampling Method:   Non-Probability Sample
Study Population

Healthy participants were recruited by advertisements in public and private institutions Patients with primary hypertension or chronic renal failure were recruited from the Out-patients' Clinic, Department of Medicine, Section of Nephrology, Holstebro Hospital

Criteria

Inclusion Criteria:

  • Patients with chronic renal insufficiency, aged between 18 and 65, both men and women
  • Creatinine clearance between 30-59 ml/min
  • Patients with hypertension, aged between 18 and 65, both men and women; hypertension is defined as a mean arterial blood pressure in the daytime that is more than 140/90 mm Hg.
  • Healthy volunteers, aged between 18 and 65, both men and women

Exclusion Criteria:

  • Clinical signs or history of disease in the heart, lungs, liver, brain, and endocrine organs
  • Cancer
  • Alcohol abuse
  • Medicine abuse
  • Pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00313430

Locations
Denmark
Department of Medicine, Holstebro Hospital
Holstebro, Ringkjoebing, Denmark, 7500
Sponsors and Collaborators
Regional Hospital Holstebro
Investigators
Study Chair: Erling B Pedersen, Professor Holstebro, Holstebro, Denmark
  More Information

No publications provided by Regional Hospital Holstebro

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Holstebro Hospital, Erling Bjerregaard Pedersen
ClinicalTrials.gov Identifier: NCT00313430     History of Changes
Other Study ID Numbers: MED. RES.HOS 2004 03/IT
Study First Received: April 11, 2006
Last Updated: February 28, 2010
Health Authority: Denmark: Ethics Committee

Keywords provided by Regional Hospital Holstebro:
Urine concentration ability
chronic renal insufficiency
hypertension
aquaporin2
Patients with chronic renal insufficiency
Patients with hypertension
Healthy volunteers

Additional relevant MeSH terms:
Hypertension
Kidney Diseases
Renal Insufficiency
Kidney Failure, Chronic
Renal Insufficiency, Chronic
Vascular Diseases
Cardiovascular Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on October 19, 2014