Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dementia/Mild Cognitive Impairment
Recruitment status was Recruiting
This study aims to determine whether levodopa is effective in boosting learning and memory in healthy subjects and patients with dementia or Mild Cognitive Impairment.
We also examine in healthy subjects using functional magnetic resonance imaging which brain regions mediate improved learning after levodopa administration.
Mild Cognitive Impairment
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Primary Purpose: Treatment
|Official Title:||Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Dementia/MCI)|
- Cognitive performance assessed by neuropsychological tests and learning paradigms under placebo and levodopa in healthy subjects and patients with dementia or Mild Cognitive Impairment.
- Brain activity pattern during learning under levodopa as compared to placebo in healthy subjects.
- Long-term stability of learning performance after 1 month in healthy subjects.
|Study Start Date:||January 2006|
|Estimated Study Completion Date:||March 2008|
Prior work of our group shows that the dopamine precursor levodopa markedly improves word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind trial, we probe whether administration of levodopa improves learning performance as compared to placebo administration on neuropsychological tests and in an associative learning paradigm. We postulate that levodopa improves learning success and memory performance in healthy subjects, while the effect in patients with dementia or Mild Cognitive Impairment might depend on other factors, including severity of memory impairment.
|Contact: Bernward Winter, MSc||+49-251-83 ext email@example.com|
|University of Muenster, Department of Neurology||Recruiting|
|Muenster, North-Rhine Westphalia, Germany, 48129|
|Principal Investigator:||Stefan Knecht, MD||Neurology, University of Muenster, Germany|
|Principal Investigator:||Caterina Breitenstein, PhD||Neurology, University of Muenster, Germany|
|Study Director:||Julia Reinholz, PhD||Neurology, University of Muenster, Germany|