Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses

This study has been completed.
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00304967
First received: March 18, 2006
Last updated: March 5, 2008
Last verified: March 2007
  Purpose

This study will use a method called dynamic light scattering (DLS) to study the lens of the eye in young normal subjects. The DLS device uses a very dim laser light to study the lens of the eye. It detects proteins in the lens, identifying early changes that may make the device useful in future cataract studies. This study will use DLS to examine the characteristics of proteins in healthy young lenses that can be used for comparison with lenses in older people and people with cataracts.

Normal volunteers aged 5 to 21 years may be eligible for this study. Participants undergo the following procedures:

Medical history

Eye examination with dilation to include:

  • Measurement of visual acuity
  • Examination of pupils and eye movements
  • Examination of the front of the eye (cornea, lens) with a slit lamp bio-microscope
  • Examination of retina with an ophthalmoscope (instrument with a strong light and magnifying lens)
  • Dynamic light scattering

Condition
Healthy

Study Type: Observational
Official Title: A Study of Crystalline Proteins in Young Normal Lenses Using the NASA-NEI Dynamic Light Scattering (DLS) Device

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 30
Study Start Date: March 2006
Estimated Study Completion Date: March 2007
Detailed Description:

The NASA-NEI Dynamic Light Scattering (DLS) device detects early molecular lens changes before clinical means are able to detect any lens changes in animal and limited human studies. This ability will make it very useful in future clinical studies of cataract etiology as well as treatment. A recently concluded clinical cross sectional study of lenses (in vivo) using the DLS device showed good reproducibility and good correlation with clinical cataract grading. It also detected remarkable changes in the lens crystalline proteins with aging and with cataract formation. We therefore propose to study the characteristics of the crystalline proteins in pristine young normal lenses with DLS for comparison with aging and cataractous lens findings. We will examine 30 young normal subjects, perform undilated eye examinations, and obtain DLS measurements of their lenses. We will then use these DLS measurements for comparison with the previously obtained aging and cataract DLS measurements, to obtain normative data for future lens and cataract clinical studies.

  Eligibility

Ages Eligible for Study:   5 Years to 21 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA

The study will enroll 30 normal control subjects, aged 5-21 years. Eligible participants must have normal clear lenses as determined by the eye examination.

EXCLUSION CRITERIA

Individuals who cannot cooperate or keep still for the DLS measurements will be excluded.

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00304967

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00304967     History of Changes
Other Study ID Numbers: 060117, 06-EI-0117
Study First Received: March 18, 2006
Last Updated: March 5, 2008
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Cataract
Normal Lenses
Lens Crystallines
Dynamic or Quasielastic Light Scattering (DLS)
Eye Examinations
Healthy Volunteer
HV
Eye Examination

ClinicalTrials.gov processed this record on July 23, 2014