Fecal Bacterial Flora in Clostridium Difficile-Associated Diarrhea
The investigators propose to study intensively the bacteriology of feces in C. difficile associated diarrheal disease, using a variety of conventional and very up-to-date techniques.
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Fecal Bacterial Flora in Clostridium Difficile-Associated Diarrhea|
|Study Start Date:||October 2005|
|Study Completion Date:||January 2007|
|Primary Completion Date:||January 2007 (Final data collection date for primary outcome measure)|
Clostridium difficile associated colitis is an increasing problem in hospitals throughout the developed world; the number of cases has increased, and the failure to respond to conventional therapy has become far more common. The investigators have recently documented in the medical literature (Clin Infect Dis, June, 2005; Lancet Infect Dis, August, 2005). Possible reasons for failure of treatment include persistence of C. difficile and/or imbalance of other bacterial flora in the colon. The bacteriology of fecal flora in C. difficile associated diarrhea has not been studied.
|United States, Maryland|
|Johns Hopkins Medical Research Institute|
|Baltimore, Maryland, United States, 21205|
|United States, Texas|
|Michael E. DeBakey Veterans Affairs Medical Center|
|Houston, Texas, United States, 77030|
|Principal Investigator:||Daniel M Musher, M.D.||Baylor College of Medicine, Houston VA Medical Center|