Assessment of the Ability to Distinguish Odors in Glaucoma Patients - Full Text View

Assessment of the Ability to Distinguish Odors in Glaucoma Patients

This study has been completed.

Sponsored by:	University Hospital, Basel, Switzerland
Information provided by:	University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:	NCT00304824

Purpose

Glaucoma is one of the leading causes of blindness worldwide. The key feature of glaucoma is damage to the optic nerve head with loss of retinal ganglion cells and local tissue remodeling. Neuronal cell death in glaucoma occurs by apoptotic mechanisms1. Apoptosis of neurons also plays a major role in neurodegenerative diseases, such as Alzheimer's or Parkinson's disease. An association between glaucoma and these disorders has been described 2-4. Furthermore, it has been reported that the olfactory function is disturbed in these neurodegenerative diseases5-6. We hypothesize that similar olfactory alterations may occur in glaucoma which is in fact a local neurodegenerative disease.

Condition

Glaucoma

Genetics Home Reference related topics:

early-onset glaucoma

MedlinePlus related topics:

Degenerative Nerve Diseases Glaucoma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Cross-Sectional, Case Control, Prospective Study

Official Title:	Olfactory Function in Glaucoma Patients

Further study details as provided by University Hospital, Basel, Switzerland:

Enrollment:	30
Study Start Date:	October 2004
Study Completion Date:	November 2005

Show Detailed Description

Eligibility

Ages Eligible for Study:	17 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Chronic open-angle glaucoma with typical glaucomatous disc and visual field damage.

Exclusion Criteria:

Occludable iridocorneal angles
History of current, chronic or recurrent inflammatory eye disease
History of retinal or neuroophthalmologic disease that could result in visual field defects
Need for any concomitant medications that may interfere with the evaluation of olfactory function
Patients with a significant history and/or active alcohol or drug abuse (significant is defined as that which in the opinion of the investigator may either put the patient at risk because of participation in the study or may influence the results of the study or the patient's ability to participate in the study), smokers
History of olfactory disturbance related to identifiable local factors and any local condition that could lead to hyposmia/anosmia or interfere with the olfactory function, such as polyps, chronic sinus infection, sub(acute) viral or bacterial infection, history of sinus surgery

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00304824

Sponsors and Collaborators

University Hospital, Basel, Switzerland

Investigators


Study Director:	Selim Orgul	University Eye Hospital Basel, Switzerland

More Information

University Basel, Switzerland This link exits the ClinicalTrials.gov site

Study ID Numbers:	009-Guk-2004-002
First Received:	March 17, 2006
Last Updated:	September 4, 2007
ClinicalTrials.gov Identifier:	NCT00304824
Health Authority:	Switzerland: Swissmedic

Keywords provided by University Hospital, Basel, Switzerland:

Glaucoma

Olfactory functions

Sniffin Sticks Test

Study placed in the following topic categories:

Glaucoma

Eye Diseases

Hypertension

Ocular Hypertension

ClinicalTrials.gov processed this record on September 05, 2008