Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

This study has been completed.
Sponsor:
Information provided by:
Vilnius University
ClinicalTrials.gov Identifier:
NCT00300794
First received: March 7, 2006
Last updated: November 13, 2006
Last verified: November 2006
  Purpose

The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).


Condition Intervention Phase
Opiate Dependence
Drug: Ketamine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Vilnius University:

Estimated Enrollment: 60
Study Start Date: February 2003
Estimated Study Completion Date: June 2006
  Eligibility

Ages Eligible for Study:   18 Years to 35 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
  • Duration of substance abuse more than 1 year
  • No or minor co-morbidities;
  • Grade I-II according to physical status classification system of American Society of Anesthesiologists.

Exclusion Criteria:

  • Current history of long acting opiate or poly-substance abuse;
  • Acute medical or surgical condition;
  • Pregnancy;
  • Breastfeeding.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00300794

Locations
Lithuania
Vilnius University Emergency Hospital
Vilnius, Lithuania
Sponsors and Collaborators
Vilnius University
Investigators
Study Director: Juozas Ivaskevicius, Prof. Vilnius University Clinic of Anaesthesiology and Intensive Care
Principal Investigator: Tomas Jovaisa, MD Vilnius University Clinic of Anaesthesiology and Intensive Care
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00300794     History of Changes
Other Study ID Numbers: PROT N1 V1_5
Study First Received: March 7, 2006
Last Updated: November 13, 2006
Health Authority: Lithuania: State Medicine Control Agency - Ministry of Health

Additional relevant MeSH terms:
Opioid-Related Disorders
Substance-Related Disorders
Mental Disorders
Ketamine
Anesthetics, Dissociative
Anesthetics, Intravenous
Anesthetics, General
Anesthetics
Central Nervous System Depressants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics
Sensory System Agents
Peripheral Nervous System Agents

ClinicalTrials.gov processed this record on April 17, 2014